- Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia).
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The commercially important antihyperglycemic agent Rosiglitazone 1(Avandia) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.
- Li, Xin,Abell, Chris,Warrington, Brian H,Ladlow, Mark
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- An alternative synthetic route for an antidiabetic drug, rosiglitazone
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A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10 h.
- Jawale, Dhanaji V.,Pratap, Umesh R.,Mane, Ramrao A.
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p. 924 - 928
(2012/03/26)
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