666846-74-8Relevant academic research and scientific papers
Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia).
Li, Xin,Abell, Chris,Warrington, Brian H,Ladlow, Mark
, p. 4392 - 4395 (2003)
The commercially important antihyperglycemic agent Rosiglitazone 1(Avandia) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.
An alternative synthetic route for an antidiabetic drug, rosiglitazone
Jawale, Dhanaji V.,Pratap, Umesh R.,Mane, Ramrao A.
, p. 924 - 928 (2012/03/26)
A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10 h.
