- METHOD FOR PRODUCING SULFONAMIDE COMPOUND
-
PROBLEM TO BE SOLVED: To provide a method for producing a compound (I) which is excellent in reactivity, stirring performance and production workability, achieves high quality of a production intermediate and is suitable for production on an industrial scale in comparison with a conventional production method. SOLUTION: There is provided a method for producing a compound (4) which comprises: (i) chlorinating a compound (1) by reacting with a chlorination agent to obtain a compound (2); and (ii) subjecting the compound (2) to a coupling reaction with a compound (3) in the presence of a palladium catalyst to obtain a compound (4). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
- -
-
Paragraph 0011; 0027-0029
(2018/05/15)
-
- Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one
-
By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.
- Wang, Mengzhou,Zhang, Yanyan,Wang, Tao,Wang, Chao,Xue, Dong,Xiao, Jianliang
-
supporting information
p. 1976 - 1979
(2016/06/01)
-
- Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.
-
PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.
- -
-
Paragraph 0621; 0622
(2018/10/03)
-