66729-00-8

Basic information

• Product Name: 4-Chloroisoquinolin-3-aMine
• Synonyms: 4-Chloroisoquinolin-3-aMine
• CAS NO: 66729-00-8
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.61828
• Mol File: 66729-00-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330.4°C at 760 mmHg
• Flash Point: 153.6°C
• Appearance: /
• Density: 1.363g/cm³
• Vapor Pressure: 0.000167mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloroisoquinolin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloroisoquinolin-3-aMine(66729-00-8)
• EPA Substance Registry System: 4-Chloroisoquinolin-3-aMine(66729-00-8)

Safety Data

• Hazardous Substances Data: 66729-00-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7ClN2/c10-8-7-4-2-1-3-6(7)5-12-9(8)11/h1-5H,(H2,11,12)

Upstream product

• 101860-70-2 4-chloro-3-nitroisoquinoline 
• 36718-46-4 3-nitro-isoquinolin-4-ol 
• 25475-67-6 isoquinolin-3-amine 
• 3336-49-0 4-isoquinolinol 

Downstream Products

• 1400699-63-9 ethyl 4-[(4-cyclopropylisoquinolin-3-yl){[4-(trifluoromethoxy)phenyl]methyl}sulfamoyl]benzoate 
• 25475-67-6 isoquinolin-3-amine 

Relevant articles and documents

METHOD FOR PRODUCING SULFONAMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a compound (I) which is excellent in reactivity, stirring performance and production workability, achieves high quality of a production intermediate and is suitable for production on an industrial scale in comparison with a conventional production method. SOLUTION: There is provided a method for producing a compound (4) which comprises: (i) chlorinating a compound (1) by reacting with a chlorination agent to obtain a compound (2); and (ii) subjecting the compound (2) to a coupling reaction with a compound (3) in the presence of a palladium catalyst to obtain a compound (4). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.