66729-00-8

Usage

InChI:InChI=1/C9H7ClN2/c10-8-7-4-2-1-3-6(7)5-12-9(8)11/h1-5H,(H2,11,12)

Upstream product

• 101860-70-2 4-chloro-3-nitroisoquinoline 
• 36718-46-4 3-nitro-isoquinolin-4-ol 
• 25475-67-6 isoquinolin-3-amine 
• 3336-49-0 4-isoquinolinol 

Downstream Products

• 25475-67-6 isoquinolin-3-amine 
• 1400699-63-9 ethyl 4-[(4-cyclopropylisoquinolin-3-yl){[4-(trifluoromethoxy)phenyl]methyl}sulfamoyl]benzoate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING SULFONAMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a compound (I) which is excellent in reactivity, stirring performance and production workability, achieves high quality of a production intermediate and is suitable for production on an industrial scale in comparison with a conventional production method. SOLUTION: There is provided a method for producing a compound (4) which comprises: (i) chlorinating a compound (1) by reacting with a chlorination agent to obtain a compound (2); and (ii) subjecting the compound (2) to a coupling reaction with a compound (3) in the presence of a palladium catalyst to obtain a compound (4). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.