- A Convergent Approach to the Dihydrotachysterol Diene System. Application to the Synthesis of Dihydrotachysterol2 (DHT2), 25-Hydroxydihydrotachysterol2 (25-OH-DHT2), 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-Hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2
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Total synthesis of A-ring fragments of 10(S),19-dihydrovitamins D and 10(R),19-dihydro-(5E)-epivitamins D from (+)-(S)-carvone and (-)-(R)-carvone is described.These fragments were used for convergent synthesis of dihydrotachysterol2 (DHT2), 25-hydroxydihydrotachysterol2, 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2.
- Maestro, Miguel A.,Castedo, Luis,Mourino, Antonio
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p. 5208 - 5213
(2007/10/02)
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- Method of treating Alzheimer's disease
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The method of treating Alzheimer's disease which comprises administering to a patient having the disease a safe and effective amount of a biologically active vitamin D3 or D2 material.
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- Hydrotitanation-Protonation of Vitamin D2 and Its Analogues: An Efficient Method for the Preparation of 10,19-Dihydrovitamins D2 Including Dihydrotachysterol2
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In this study we describe an easy and efficient method for the preparation of the known 10,19-dihydrovitamins D2 2b (DHV2-II), 2c (DHV2-IV), 3c (dihydrotachysterol2, DHT2), and the new dihydrovitamins D2 2f and 2g.This method is based on the regioselective hydrometalation reaction of vitamin D2 and its derivatives with the system Cp2TiCl2-LiAlH4 or Cp2TiCl2-Red-Al (Aldrich).Under optimal conditions, the reaction with the former of these hydrometalating systems takes place with a high degree of stereoselectivity and allows labelling at C-19.
- Cota, J. G.,Meilan, M. C.,Mourino, A.,Castedo, L.
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p. 6094 - 6099
(2007/10/02)
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- Administration of biologically active vitamin D3 and vitamin D2 materials
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A process for administering biologically active vitamin D3 and vitamin D2 materials into the blood system of a subject by providing the biologically active vitamin D3 or D2 material to the skin whereby the skin releases the biologically active vitamin D3 or D2 material into the blood system in a controlled and prolonged manner.
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- Administration of biologically active vitamin D3 and vitamin D2 materials
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A process for administering biologically active vitamin D3 and vitamin D2 materials into the blood system of a subject by providing the biologically active vitamin D3 or D2 material to the skin whereby the skin releases the biologically active vitamin D3 or D2 material into the blood system in a controlled and prolonged manner.
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