67-96-9 Usage
Description
Dihydrotachysterol is a synthetic analog of vitamin D. It is considered as a reduction product of vitamin D2 (ergocalciferol). It stimulates bone mineralization as well as calcium and phosphorus absorption in intestine. Dihydrotachysterol has been used for the treatment of hypoparathyroidism, osteomalacia, osteoporosis, low calcium level, and kidney osteodystrophy. Though dihydrotachysterol is more expensive, dihydrotychysterol therapy is preferred as it has a more rapid onset of action (1-7 d) and a shorter time for dissipation of effect in the event of toxicity (2-3 weeks) than vitamin D2.
Pharmacodynamics
Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1,25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. It also increases renal phosphate excretion. In contrast to parathyroid extract, dihydrotachysterol is active when taken orally, exerts a slow but persistent effect, and may be used for long periods without increasing the dosage or causing tolerance. Dihydrotachysterol is faster-acting than pharmacologic doses of vitamin D and is less persistent after cessation of treatment, thus decreasing the risk of accumulation and of hypercalcemia.
Indication
Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Uses
Different sources of media describe the Uses of 67-96-9 differently. You can refer to the following data:
1. Dihydrotachysterol is a form of vitamin D. Vitamin D is a fat-soluble vitamin and has properties of both vitamins and minerals. Vitamin D helps you to absorb calcium from what you eat. You need calcium to keep your bones strong, and to help your muscles and nerves work properly.
The term Vitamin D collectively refers to a group of structurally similar chemicals and their metabolites, which includes alfacalcidol (1 α hydroxycholecalciferol), calcitriol (1,25-dihydroxychole-calciferol), cholecalciferol (Vitamin D3), dihydrotachysterol(DHT) and ergocalciferol (Vitamin D2). These agents have antirachitic properties.
Dihydrotachysterol-2 (DHT-2) is a vitamin D2 analog for the Pharmaceutical industry.
Dihydrotachysterol-2 is used in the prevention and treatment of several bone growth disorders such as osteoporosis. Besides this the substance is also used to treat several abnormalities of the parathyroid glands such as hypoprathyroidism.
2. Calcium regulator. Preparation by reduction of Tachysterol. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.
References
https://en.wikipedia.org/wiki/Dihydrotachysterol
https://www.drugbank.ca/drugs/DB01070
https://pubchem.ncbi.nlm.nih.gov
Jack Z. Yetiv and Joseph R. Bianchine, Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders, 1981, ISBN 0-12-788950-7
Carl P. Weiner and Kate Rope, The Complete Guide to Medications During Pregnancy and Breastfeeding, 2013, ISBN-10: 0312676468
Chemical Properties
White Solid
Originator
Hytakerol,Winthrop,US,1950
Definition
ChEBI: A hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent.
Manufacturing Process
The process of isolating chemically uniform crystalline dihydrotachysterol
comprises subjecting the solution of the crude hydrogenation product of
tachysterol in benzine to chromatographic adsorption by means of active
aluminum oxide while collecting the components having a minor tendency of
being adsorbed, subjecting the said components to a repeated
chromatographic adsorption and converting the components having a minor
tendency of being adsorbed into its ester by treatment with acetic anhydride
in pyridine solution, isolating the ester formed from the reaction mixture,
subjecting its solution in benzine to chromatographic adsorption while
collecting the components having a minor tendency of being adsorbed,
recrystallizing these components, saponifying the crystalline ester and
recrystallizing the dihydrotachysterol obtained.
Brand name
Hytakerol (Sterling Winthrop).
Therapeutic Function
Blood calcium regulator
Veterinary Drugs and Treatments
DHT is used in small animals to treat hypocalcemia secondary to
hypoparathyroidism
or severe renal disease.
Purification Methods
Crystallise the sterol from 90% MeOH, UV: max at 242, 251 and 261nm (E1% 760, 1010 and 650) in EtOH. The acetate has m108-110o and [] +32.8o (CHCl3), UV: max at 242, 251 and 261nm (E 780, 910 and 600) in EtOH. The propionate has m 97-98o and [] +37o (CHCl3), UV: max 242, 251 and 261nm (E 750, 860 and 570) in EtOH. [Werder Hoppe Seyler's Z Physiol Chem 260 119 1939, Windaus et al. Justus Liebigs Ann Chem 499 1978 1932, Beilstein 6 III 2833, 6 IV 3994, 4161.]
Check Digit Verification of cas no
The CAS Registry Mumber 67-96-9 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67-96:
(4*6)+(3*7)+(2*9)+(1*6)=69
69 % 10 = 9
So 67-96-9 is a valid CAS Registry Number.
InChI:InChI=1/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+
67-96-9Relevant articles and documents
A Convergent Approach to the Dihydrotachysterol Diene System. Application to the Synthesis of Dihydrotachysterol2 (DHT2), 25-Hydroxydihydrotachysterol2 (25-OH-DHT2), 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-Hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2
Maestro, Miguel A.,Castedo, Luis,Mourino, Antonio
, p. 5208 - 5213 (2007/10/02)
Total synthesis of A-ring fragments of 10(S),19-dihydrovitamins D and 10(R),19-dihydro-(5E)-epivitamins D from (+)-(S)-carvone and (-)-(R)-carvone is described.These fragments were used for convergent synthesis of dihydrotachysterol2 (DHT2), 25-hydroxydihydrotachysterol2, 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2.
Hydrotitanation-Protonation of Vitamin D2 and Its Analogues: An Efficient Method for the Preparation of 10,19-Dihydrovitamins D2 Including Dihydrotachysterol2
Cota, J. G.,Meilan, M. C.,Mourino, A.,Castedo, L.
, p. 6094 - 6099 (2007/10/02)
In this study we describe an easy and efficient method for the preparation of the known 10,19-dihydrovitamins D2 2b (DHV2-II), 2c (DHV2-IV), 3c (dihydrotachysterol2, DHT2), and the new dihydrovitamins D2 2f and 2g.This method is based on the regioselective hydrometalation reaction of vitamin D2 and its derivatives with the system Cp2TiCl2-LiAlH4 or Cp2TiCl2-Red-Al (Aldrich).Under optimal conditions, the reaction with the former of these hydrometalating systems takes place with a high degree of stereoselectivity and allows labelling at C-19.
Administration of biologically active vitamin D3 and vitamin D2 materials
-
, (2008/06/13)
A process for administering biologically active vitamin D3 and vitamin D2 materials into the blood system of a subject by providing the biologically active vitamin D3 or D2 material to the skin whereby the skin releases the biologically active vitamin D3 or D2 material into the blood system in a controlled and prolonged manner.
