- Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method
-
The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .
- -
-
Paragraph 0065
(2019/03/28)
-
- Thiazolyl-benzimidazoles
-
The invention is directed to compounds of formula (1) [image] and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
- -
-
Page/Page column 41
(2008/06/13)
-
- Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
-
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
- -
-
-
- Compositions for dyeing keratinous fiber
-
A composition for dyeing keratinous fiber which includes incorporated therein an oxidative color-developing substance, an enzyme which reacts with oxygen as a substrate but does not evolve hydrogen peroxide, and a weak reducing agent.
- -
-
-
- Synthesis of 4-Amino-7-hydroxybenzimidazole
-
A simple and efficient synthesis of 4-amino-7-hydroxybenzimidazole (2a) was developed involving condensation of 2,3-diaminophenol with triethyl orthoformate, coupling the 4-hydroxybenzimidazole (6) thus obtained with 4-ethylbenzodiazonium chloride to give 4-(4-ethylphenylazo)-7-hydroxybenzimidazole (7) and hydrogenolysis of 7 to give 2a.Acetylation of 2a with acetic anhydride gave triacetyl derivative (8), the structure of which was proved by X-ray crystallographic analysis.
- Katritzky, Alan R.,Rachwal, Bogumila,Rachwal, Stanislaw,Steel, Peter J.,Zaklika, Krzysztof A.
-
p. 2415 - 2422
(2007/10/02)
-
