67036-49-1Relevant articles and documents
Fluoroquinolone such amino derivative and use thereof (by machine translation)
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Paragraph 0104; 0105; 0108; 0111, (2018/04/26)
The invention belongs to the field of pharmaceutical chemistry, and in particular relates to a fluoroquinolone derivatives and use thereof. The invention through structural modification of the fluoroquinolone drugs such as shown in formula I, the compounds of the invention not only can the Mycobacterium tuberculosis and the normal bacterial caused by the treatment of infection, bacteria also holds keeps the fungus, citrus pathogens, nicotinamide N - methyltransferase (NNMT) and interleukin IL - 17 PPI has inhibitory activity. The compounds of the invention preparation process operation is convenient, mild condition, to obtain the antibacterial activity is enhanced, water-soluble improve, many compounds toxic side effects, it is expected to reduce the amount of medicine used, shorten the treatment cycle, improve patient's compliance, for tuberculosis drug and other disease research provide new molecular type with the study. (by machine translation)