6705-31-3

Basic information

• Product Name: 2-(2'-HYDROXYETHYL)PYRAZINE
• Synonyms: 2-(2'-HYDROXYETHYL)PYRAZINE;2-(2-HYDROXYETHYL)-PYRAZINE;2-pyrazin-2-ylethanol;(2-Hydroxyethyl)pyrazine;2-Pyrazineethanol;2-Pyrazinylethyl alcohol;pyrazine-2-ethanol;2-(pyrazin-2-yl)ethano
• CAS NO: 6705-31-3
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• Product Categories: pharmacetical;Piperazines
• Mol File: 6705-31-3.mol

Chemical Properties

• Boiling Point: 236℃
• Flash Point: 96℃
• Appearance: /
• Density: 1.168
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.5378 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.52±0.10(Predicted)
• CAS DataBase Reference: 2-(2'-HYDROXYETHYL)PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2'-HYDROXYETHYL)PYRAZINE(6705-31-3)
• EPA Substance Registry System: 2-(2'-HYDROXYETHYL)PYRAZINE(6705-31-3)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 6705-31-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2O/c9-4-1-6-5-7-2-3-8-6/h2-3,5,9H,1,4H2

Upstream product

• 109-08-0 2-Methylpyrazine 
• 50-00-0 formaldehyd 
• 66-84-2 D-(+)-glucosamine hydrochloride 
• 109-07-9 (RS)-2-methylpiperazine 

Downstream Products

• 4177-16-6 2-vinylpyrazine 
• 126473-97-0 β-(2-propynyloxy)ethylpyrazine 
• 322732-66-1 5'-O-(monomethoxytrityl)thymidine 3'-[2,5-dichlorophenyl 2-(pyrazin-2-yl)ethyl phosphate] 
• 65210-60-8 7,8-dihydro-5H-pyrano[4,3-b]pyridine 
• 126474-06-4 3,4-Dihydro-1H-pyrano[4,3-c]pyridine 
• 126474-21-3 8-Trimethylsilanyl-3,4-dihydro-1H-pyrano[4,3-c]pyridine 
• 126474-20-2 4-Trimethylsilanyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine 
• 126474-12-2 2-[2-(3-Trimethylsilanyl-prop-2-ynyloxy)-ethyl]-pyrazine 
• 3388-79-2 2-(2-hydroxyethyl)piperazine 
• 1196093-34-1 2-(2-bromo-ethyl)-pyrazine 
• 1196091-31-2 (R)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-(2-pyrazin-2-yl-ethyl)-azonia-bicyclo[2.2.2]octane bromide 

Relevant articles and documents

Degradation Products Fromed from Glucosamine in Water

An aqueous solution of glucosamine hydrochloride was heated to 150 °C for 5 min under different pH conditions. The reaction product mixture obtained was analyzed by GC/MS. It was found that the major products formed were furfurals, especially at pH = 4 and 7. At pH = 8.5, additional flavor components were generated, including pyrazines, 3-hydroxypyridines, pyrrole-2-carboxaldehyde, furans, acetol, and several other compounds. Of the components identified, it is worthwhile to note the formation of pyrazine and methylpyrazine as major components at pH = 8.5. It is proposed that a retro-aldol condensation plays an important role in the formation of the intermediates, α-aminoacetaldehyde (I) and α-amino propanal (II). As a result, self-condensation of I generates pyrazine and combination of I and II generates methylpyrazine. In addition, it is also interesting to note the formation of 3-hydroxypyridines and pyrrole-2-carboxaldehyde. It is suggested that both groups of compounds are derived from furfurals. As the ammonia is liberated from glucosamine, it initiates the ring-opening of furfurals to form 5-amino-2-keto-3-pentenals. Intramolecular condensations of these intermediates between the amino group and the carbonyl groups lead to the formation of 3-hydroxypyridines and pyrrole-2-carboxalhyde.

N,N-diacylpiperazine tachykinin antagonists

Diacylpiperazines of general structure STR1 are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.