This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.
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Page/Page column 31-32
(2011/02/24)
Antitumor Properties of 2(1H)-Pyrimidinone Riboside (Zebularine) and Its Fluorinated Analogues
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and evaluated in vivo as antitumor agents.Zebularine provides increase in life span (ILS) values of ca. 70percent against intraperito
Driscoll, John S.,Marquez, Victor E.,Plowman, Jacqueline,Liu, Paul S.,Kelley, James A.,Barchi, Joseph J.
p. 3280 - 3284
(2007/10/02)
Pyrimidine derivatives; 1. The highly regioselective 4-thionation of pyrimidine-2,4(1H,3H)-dione derivatives with Lawesson reagent
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Kaneko,Katayama,Wakabayashi,Kumonaka
p. 152 - 154
(2007/10/02)
A Rapid and Efficient Synthesis of Sulfur Analogues of Pyrimidine Bases
An improved procedure for thionation of some natural pyrimidine bases with tetraphosphorus decasulfide/sodium hydrogen carbonate is reported.Some substituted uracils and 2-thiouracils were converted into a series of analogues in which the oxygen at position 4 was replaced by sulfur atom.The advantage of this method of thionation over the older procedures is based on the tetraphosphorus decasulfide/sodium hydrogen carbonate mixture giving rise to excellent yields and simplified isolation of the desired pure products.
8-[4-[4-(5-Fluoro-pyrimidin-2-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione and its pharmaceutically acceptable salts demonstrate antipsychotic activity.