- Transition-Metal-Free Radical Hydrotrifluoromethylation of Alkynes
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A combination of readily available and bench-stable CF3SO2Na and tBuOOH was efficiently used for hydrotrifluoromethylation of alkynes. An excellent trans-selectivity was demonstrated in the synthesis of alkenes. The developed mild reaction conditions allow the supression of the competing Meyer–Schuster-type rearrangement.
- Matcha, Kiran,Antonchick, Andrey P.
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supporting information
p. 309 - 312
(2019/01/24)
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- Method for efficiently preparing alkynol
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The invention relates to a method for efficiently preparing alkynol, belongs to the field of preparation of chemical intermediates and chemicals, and particularly relates to a preparation method of alkynol. The preparation method comprises the following steps that 1, alkali metal is added into an anhydrous alcohols solvent; an alcohol-alkali metal solution is prepared; 2, a compound I is added into the alcohol-alkali metal solution; uniform stirring is performed; cooling is performed to be 0 DEG C or below; 3, acetylene is introduced through being metered at normal pressure; alkynol is obtained; 4, the alkynol solution after reaction is neutralized by ammonium chloride and a same alcohol mixed suspension system; 5, the neutralized mixed suspension system is filtered; after alcohols are recovered from filter liquid, reduced pressure distillation is performed to obtain an alkynol product. The method overcomes the defect that under the existing harsh reaction conditions of high pressure,liquid ammonia and the like, the solid potassium hydroxide feeding difficulty is avoided; under the ordinary pressure condition, the ketone compounds are converted into alkynol at high conversion rate. The method has the advantages of high conversion rate, simple process and good product purity.
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Paragraph 0036; 0037; 0038; 0043; 0044; 0045; 0046
(2018/12/14)
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- Allenyl ester precursors for 1H-inden-1-ol carboxylates: Comparisons with their propargylic equivalents having terminal alkyne functions
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The reactivity of allenyl carboxylates, Ar(R1)CCCH(O 2CR2) and their isomeric equivalents the terminal propargylic carboxylates, ArC(R1)(O2CR2)CCH, in gold-catalyzed carbocyclization to ind
- Asikainen, Martta,Woodward, Simon
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experimental part
p. 5492 - 5497
(2012/09/08)
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- Hydrolytic Resolution of Tertiary Acetylenic Acetate Esters With the Lipase from Candida Cylindracea
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The kinetic resolution of a series of tertiary acetylenic acetate esters using the lipase from Candida cylindracea has been explored.Compounds 6c and the trifluoromethyl acetate 6e have been resolved with high enantiomeric enrichment.Several other tertiary acetate esters carrying a CF3 group have been investigated which proved inert to enzymatic hydrolysis.From these results and published data, we are able to propose a predictive model for identifying the preferred enantiomer of secondary and tertiary trifluoromethyl acetate esters for this lipase.
- O'Hagan, David,Zaidi, Naveed A.
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p. 947 - 949
(2007/10/02)
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- The Effect of the Structure of Substartes and Reaction Conditions on the Preparation of Acetylene 1,4-diols. II. Two-stage Syntheses
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Twelve reactions of the preparation of asymmetric acetylene 1,4-diols have been carried out (Scheme I).A significant effect of the structure of initial ketone and the reaction conditions on the preparation of diols has been found in the first stage of the synthesis (prepartion of acetylene carbinol).For R1 or R2 = p-CH3OC6H4 products of dehydration of the dils have been obtained.
- Olejnik, Marian,Jasiobedzki, Wieslaw,Pograniczna-Ramza, Maryla
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p. 467 - 473
(2007/10/02)
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- Optically active propargyl alcohol derivative and a method for preparation of the same
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An optically active propargyl alcohol derivative of the formula (I) STR1 wherein X=phenyl or thienyl and R=lower alkyl, halogenated methyl, phenyl or substituted phenyl having at least one lower alkyl radical and or halogen atom, is prepared by contacting a racemic modification of l- and d-isomers of the formula (I) with l-brucine in an organic solvent, by separating the resultant deposited diastereomer from a solution containing the resultant other diastereomer in the organic solvent, by decomposing each diastereomer with an aqueous mineral acid solution in the presence of an organic solvent capable of dissolving the corresponding optically active isomer dissociated from the diastereomer and incompatible with water so as to allow the optically active isomer to be dissolved in the water-incompatible organic solvent, and by recovering the optically active isomer from the solution thereof.
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