- Multi-hydrogen isoquinoline derivative as well as preparation method and medical application thereof
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The invention relates to a multi-hydrogen isoquinoline derivative as well as a preparation method and medical application thereof, the multi-hydrogen isoquinoline derivative is a compound as shown ina formula (I) or cis/trans isomers, enantiomers, diaster
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Paragraph 0061; 0085-0086; 0095-0096
(2020/12/30)
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- Synthesis, characterization and structural study of a phosphonium salt containing the [Pd2Br6]2- ion and its application as a novel, efficient and renewable heterogeneous catalyst for amination of aryl halides and the Stille cross-coupling reaction
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In this study palladium(II) acetate reacts with a phosphonium salt, [Ph3PCH2C6H4CH2Br]Br, to give [Ph3PCH2C6H4CH2OC(O)CH3]2[Pd2Br6]. Characterization of the obtained compound was performed by elemental analysis, IR, 1H, 31P, 13C NMR and X-ray crystallography. It was found that this compound can act as an efficient catalyst for amination of aryl halides to afford primary amines and satisfactory results were obtained. It has also been successfully employed in the catalytic Stille cross-coupling reaction. The catalyst is easily recoverable and reusable without significant loss of its catalytic activity.
- Naghipour, Ali,Ghorbani-Choghamarani, Arash,Heidarizadi, Fateme,Notash, Behrouz
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- Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents
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A structure-activity relationship study of a library of novel bifunctional GdIII complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential application in binary cancer therapies such as neutron cap
- Morrison, Daniel E.,Aitken, Jade B.,De Jonge, Martin D.,Issa, Fatiah,Harris, Hugh H.,Rendina, Louis M.
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supporting information
p. 16602 - 16612
(2015/09/29)
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- Convenient Synthesis of 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid and Its Derivatives as Doubly Constrained Nonproteinogenic Amino Acid Derivatives
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Three strategies for the synthesis of the novel, doubly constrained, 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its derivatives were evaluated. Only cyclocondensation of the mono(triphenyl)phosphonium salt derived from 1,2-bis(bromomethyl)benzene with N-alkoxycarbonyloxamates in 1,2-dimethoxyethane in the presence of potassium carbonate and subsequent cyclopropanation with dimethylsulfoxonium methylide in dimethyl sulfoxide furnished suitable O-and N-protected derivatives of 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in a convenient way. A detailed 2D DQF-COSY and 2D NOESY NMR analysis of the rotational isomerism of the latter bicyclic amino acid derivatives was performed. Various O- and N-protection protocols were worked out to afford access to a whole range of new derivatives of the title amino acid, suitable for peptide synthesis.
- Czombos, Jozsef,Aelterman, Wim,Tkachev, Alexey,Martins, Jose C.,Tourwe, Dirk,Peter, Antal,Toeth, Geza,Fueloep, Ferenc,De Kimpe, Norbert
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p. 5469 - 5475
(2007/10/03)
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- A NEW ROUTE TO HETEROCYCLIC α-DEHYDRO α-AMINO ESTERS
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Heterocyclic α-dehydro α-amino esters are obtained by the reaction of ethyl N-carbomethoxy oxamate with ω-halogened phosphorus ylids.
- Bazureau, J. P.,Le Roux, J.,Le Corre, M.
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p. 1921 - 1922
(2007/10/02)
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