67219-44-7

Usage

Uses

Used in Organic Synthesis:
2-(BROMOMETHYL)BENZYLTRIPHENYLPHOSPHONIUM BROMIDE is used as a phase transfer catalyst for facilitating the transfer of reagents between immiscible phases in various organic reactions. Its ability to promote reactions in a wide range of conditions makes it a versatile tool in the synthesis of complex organic compounds.
Used in Pharmaceutical Industry:
In the synthesis of ciprofibrate, a lipid-lowering drug, 2-(BROMOMETHYL)BENZYLTRIPHENYLPHOSPHONIUM BROMIDE serves as a crucial reagent, highlighting its application in the development of pharmaceuticals that address specific health conditions.
Used in the Preparation of Tetrahydrocarbazoles:
2-(BROMOMETHYL)BENZYLTRIPHENYLPHOSPHONIUM BROMIDE is utilized as a reagent in the preparation of tetrahydrocarbazoles, which are compounds of interest in various chemical and pharmaceutical applications due to their unique properties and potential uses.
Used in Research and Development:
2-(BROMOMETHYL)BENZYLTRIPHENYLPHOSPHONIUM BROMIDE is also employed in research and development settings to explore new reaction pathways and to improve existing synthetic methods, contributing to the advancement of organic chemistry and its applications across different industries.

InChI:InChI=1/C26H23BrP/c27-20-22-12-10-11-13-23(22)21-28(24-14-4-1-5-15-24,25-16-6-2-7-17-25)26-18-8-3-9-19-26/h1-19H,20-21H2/q+1

Upstream product

• 603-35-0 triphenylphosphine 
• 91-13-4 α,α'-dibromo-o-xylene 

Downstream Products

• 298209-94-6 ethyl 2-tert-butoxycarbonyl-1,2-dihydroisoquinoline-3-carboxylate 
• 29539-10-4 3-phenyl-1H-isochromene 
• 29539-11-5 3-(4-methoxyphenyl)-1H-isochromene 
• 77968-36-6 2-(2-Formylphenyloxymethyl)-benzyl-triphenylphosphonium bromide 

Relevant academic research and scientific papers

Multi-hydrogen isoquinoline derivative as well as preparation method and medical application thereof

The invention relates to a multi-hydrogen isoquinoline derivative as well as a preparation method and medical application thereof, the multi-hydrogen isoquinoline derivative is a compound as shown ina formula (I) or cis/trans isomers, enantiomers, diaster

Synthesis, characterization and structural study of a phosphonium salt containing the [Pd2Br6]2- ion and its application as a novel, efficient and renewable heterogeneous catalyst for amination of aryl halides and the Stille cross-coupling reaction

In this study palladium(II) acetate reacts with a phosphonium salt, [Ph3PCH2C6H4CH2Br]Br, to give [Ph3PCH2C6H4CH2OC(O)CH3]2[Pd2Br6]. Characterization of the obtained compound was performed by elemental analysis, IR, 1H, 31P, 13C NMR and X-ray crystallography. It was found that this compound can act as an efficient catalyst for amination of aryl halides to afford primary amines and satisfactory results were obtained. It has also been successfully employed in the catalytic Stille cross-coupling reaction. The catalyst is easily recoverable and reusable without significant loss of its catalytic activity.

Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents

A structure-activity relationship study of a library of novel bifunctional GdIII complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential application in binary cancer therapies such as neutron cap

Convenient Synthesis of 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid and Its Derivatives as Doubly Constrained Nonproteinogenic Amino Acid Derivatives

Three strategies for the synthesis of the novel, doubly constrained, 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its derivatives were evaluated. Only cyclocondensation of the mono(triphenyl)phosphonium salt derived from 1,2-bis(bromomethyl)benzene with N-alkoxycarbonyloxamates in 1,2-dimethoxyethane in the presence of potassium carbonate and subsequent cyclopropanation with dimethylsulfoxonium methylide in dimethyl sulfoxide furnished suitable O-and N-protected derivatives of 3,4-methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in a convenient way. A detailed 2D DQF-COSY and 2D NOESY NMR analysis of the rotational isomerism of the latter bicyclic amino acid derivatives was performed. Various O- and N-protection protocols were worked out to afford access to a whole range of new derivatives of the title amino acid, suitable for peptide synthesis.

A NEW ROUTE TO HETEROCYCLIC α-DEHYDRO α-AMINO ESTERS

Heterocyclic α-dehydro α-amino esters are obtained by the reaction of ethyl N-carbomethoxy oxamate with ω-halogened phosphorus ylids.