- FUNGICIDAL ARYL AMIDINES
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This disclosure relates to aryl amidines of Formula I and their use as fungicides. One embodiment of the present disclosure is a use of a compound of Formula I, for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of a compound of Formula I, or a composition comprising the compound to soil, a plant, a part of a plant, foliage, and/or roots.
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Paragraph 0075
(2020/12/07)
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- ASK1 INHIBITOR COMPOUNDS AND USES THEREOF
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Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non
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Paragraph 0462; 0463
(2018/11/02)
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- INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES
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The present invention relates to compounds of the general formula (I) in which R1 to R6, A, Y, X, G, n and m are each as defined in the description—and to a process for preparation thereof and to the use thereof as insecticides and a
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Paragraph 0297; 0298; 0299; 0301
(2014/04/03)
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- NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95
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We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.
- Vogrig, Alexandre,Boucherle, Benjamin,Deokar, Hemantkumar,Thomas, Isabelle,Ripoche, Isabelle,Lian, Lu-Yun,Ducki, Sylvie
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p. 3349 - 3353
(2011/07/07)
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- INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS
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There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.
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Page/Page column 30
(2009/05/30)
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- Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains
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This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ do
- Mayasundari, Anand,Ferreira, Antonio M.,He, Liwen,Mahindroo, Neeraj,Bashford, Don,Fujii, Naoaki
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p. 942 - 945
(2008/09/18)
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- Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity
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We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcript
- Mahindroo, Neeraj,Punchihewa, Chandanamali,Bail, Allison M.,Fujii, Naoaki
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p. 946 - 949
(2008/09/20)
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- SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION
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Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl)
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Page/Page column 24
(2008/06/13)
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- Indole-type derivatives as inhibitors of p38 kinase
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The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.
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Page/Page column 42
(2008/06/13)
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