672293-33-3

Basic information

• Product Name: Methyl 4-amino-5-iodo-2-methylbenzoate
• Synonyms: Methyl 4-amino-5-iodo-2-methylbenzoate;4-Amino-5-iodo-2-methyl-benzoic acid methyl ester
• CAS NO: 672293-33-3
• Molecular Formula: C₉H₁₀INO₂
• Molecular Weight: 291
• Mol File: 672293-33-3.mol

Chemical Properties

• Boiling Point: 366.952°C at 760 mmHg
• Flash Point: 175.726°C
• Appearance: /
• Density: 1.733g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.53±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-amino-5-iodo-2-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-5-iodo-2-methylbenzoate(672293-33-3)
• EPA Substance Registry System: Methyl 4-amino-5-iodo-2-methylbenzoate(672293-33-3)

Safety Data

• Hazardous Substances Data: 672293-33-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Methyl 4-amino-5-iodo-2-methylbenzoate is used as a reagent in organic synthesis for its unique functional groups, which contribute to the development of new pharmaceutical compounds.
Used in Drug Production:
As a building block, Methyl 4-amino-5-iodo-2-methylbenzoate is employed in the preparation of various pharmaceuticals, playing a crucial role in the synthesis of drugs intended to treat a range of medical conditions.
Used in Agrochemicals:
Methyl 4-amino-5-iodo-2-methylbenzoate is also utilized in the production of agrochemicals, where its chemical properties can be harnessed to develop new compounds for agricultural applications.

InChI:InChI=1/C9H10INO2/c1-5-3-8(11)7(10)4-6(5)9(12)13-2/h3-4H,11H2,1-2H3

Upstream product

• 6933-47-7 methyl 4-amino-2-methylbenzoate 
• 1975-51-5 2-methyl-4-nitrobenzoic acid 
• 30459-70-2 2-methyl-4-nitrobenzoyl chloride 
• 67-56-1 methanol 
• 90531-76-3 4-Amino-2-methyl-benzoyl chloride 

Downstream Products

• 21339-74-2 methyl 4-amino-2,5-dimethylbenzoate 
• 1015464-47-7 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid 
• 1016170-79-8 methyl 6-methyl-3-phenethyl-2-triethylsilyl-1H-indole-5-carboxylate 
• 672293-34-4 methyl 4-acetamido-5-iodo-2-methylbenzoate 

Relevant articles and documents

FUNGICIDAL ARYL AMIDINES

This disclosure relates to aryl amidines of Formula I and their use as fungicides. One embodiment of the present disclosure is a use of a compound of Formula I, for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of a compound of Formula I, or a composition comprising the compound to soil, a plant, a part of a plant, foliage, and/or roots.

ASK1 INHIBITOR COMPOUNDS AND USES THEREOF

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INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES

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NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95

We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.

INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS

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Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains

This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ do

Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity

We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcript

SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION

Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl)

Indole-type derivatives as inhibitors of p38 kinase

The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.