cas 6723-30-4, O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

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Heterocyclic inhibitors of farnesyl protein transferase
Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein:, A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or substituted phenyl;, G1 is S or O;, G2 is H, -C(O)OH, -C(O)NH2, 5-tetrazolyl, -C(O)N(R7)OH or -CH2OH;, X is O or R8N;, Y and Z are each independently -CH2- or -C(O)-;, R1, R2, R3, R4, R5, R6 and R7 are each independently H or alkyl;, R1 may also be alkanoyl, R1 and A1 taken together may be -(CH2)m;, R8 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or -C(O)R9;, R9 is H, alkyl, phenyl, phenylalkyl, substituted phenyl or (substituted phenyl)alkyl;, m is 3 or 4;, n is 0, 1 or 2;, p is 0, 1 or 2; and, q is 0 or 1, with the proviso that when p is 0, then q is also 0.
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(2008/06/13)

Arylhydroxamates useful as antiallergy agents
Arylhydroxamates are provided having the structure STR1 wherein R1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkenyl, aralkyl, or STR2 wherein n is 1 to 4 and X is hydroxy, alkoxy, amino, C1 -C4 -alkylamino or C1 -C4 -dialkylamino. R2 is hydrogen or lower alkyl; and R3 is C1 -C20 alkyl or C3 -C20 alkenyl, aryl, aryl-alkyl, cycloalkyl, aryl-alkenyl, lower alkoxy, lower alkenyloxy, aryl-alkoxy or cycloalkyloxy. These compound are useful as inhibitors of Δ5 -lipoxygenase and as such are useful as antiallergy agents.
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(2008/06/13)

Chemical Properties

Melting Point: 34-37 °C(lit.)
Boiling Point: 209.322 °C at 760 mmHg
Flash Point:94.498 °C
Density: 1.069 g/cm³
Solubility:DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Vapor Pressure: 0.204mmHg at 25°C
Refractive Index: 1.463
PKA: 3.28±0.20(Predicted)
PSA: 44.48000
LogP: 1.10360

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6723-30-4

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Chemical Properties

Melting Point: 34-37 °C(lit.)

Boiling Point: 209.322 °C at 760 mmHg

Flash Point:94.498 °C

Density: 1.069 g/cm³

Solubility:DMSO (Slightly), Methanol (Slightly)

Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Vapor Pressure: 0.204mmHg at 25°C

Refractive Index: 1.463

PKA: 3.28±0.20(Predicted)

PSA: 44.48000

LogP: 1.10360

Global suppliers and manufacturers of 6723-30-4total 97 suppliers on LookChem

Article Database

6723-30-4

Articles about 6723-30-4Total 2 be found

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Chemical Properties

Melting Point: 34-37 °C(lit.)

Boiling Point: 209.322 °C at 760 mmHg

Flash Point:94.498 °C

Density: 1.069 g/cm3

Solubility:DMSO (Slightly), Methanol (Slightly)

Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Vapor Pressure: 0.204mmHg at 25°C

Refractive Index: 1.463

PKA: 3.28±0.20(Predicted)

PSA: 44.48000

LogP: 1.10360

Global suppliers and manufacturers of 6723-30-4total 97 suppliers on LookChem

Density: 1.069 g/cm³