6723-30-4

Usage

Uses

1. Used in Pharmaceutical Applications:
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as a therapeutic agent for treating fibrotic and inflammatory diseases. Its application in this field is due to its potential to alleviate the symptoms and progression of these conditions.
2. Used in Chemical Synthesis:
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid, which has demonstrated significant inhibitory activity against mycothiol S-conjugate amidase. This application highlights its utility in the development of novel compounds with potential biological activities.
3. Used in DNA Analysis:
The coupling of O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine with alkaline gel electrophoresis has been reported to improve the process of detecting single-strand breaks (SSBs) in DNA. This application underscores its role in enhancing the accuracy and efficiency of DNA damage assessment techniques.

InChI:InChI=1/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

Downstream Products

• 112800-52-9 2-Hydroxy-3-phenyl-N-(tetrahydro-2H-2-pyranyloxy)-2-(2-thienyl)propanamid 
• 76440-71-6 2-Hydroxy-N-(tetrahydro-2H-2-pyranyloxy)phenylacetamid 
• 131662-01-6 N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine 
• 308385-92-4 2-(4-phenyl-piperidine-1-sulfonyl)-N-(tetrahydro-pyran-2-yloxy)-benzamide 
• 308385-97-9 2-(4-phenoxy-phenylsulfamoyl)-N-(tetrahydro-pyran-2-yloxy)-benzamide 
• 213012-85-2 2-(4-benzyl-piperidine-1-sulfonyl)-N-(tetrahydro-pyran-2-yloxy)-benzamide 
• 308385-99-1 N-(tetrahydro-pyran-2-yloxy)-2-[3-(4-trifluoromethyl-phenoxy)-pyrrolidine-1-sulfonyl]-benzamide 
• 308385-93-5 C₂₄H₂₉N₃O₇S 
• 308385-95-7 N-(tetrahydro-pyran-2-yloxy)-2-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide 
• 308385-94-6 N-(tetrahydro-pyran-2-yloxy)-2-[4-(4-trifluoromethoxy-phenoxy)-piperidine-1-sulfonyl]-benzamide 
• 308385-96-8 N-(tetrahydro-pyran-2-yloxy)-2-[4-(4-trifluoromethyl-benzyloxy)-piperidine-1-sulfonyl]-benzamide 
• 308386-00-7 2-fluoro-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide 
• 1035211-61-0 4-(4-benzenesulfonylamino-phenyl)-N-(tetrahydro-pyran-2-yloxy)-butyramide 
• 688045-11-6 N-(tetrahydro-pyran-2-yloxy)-3-[4-(toluene-4-sulfonylamino)-phenyl]-acrylamide 

Relevant academic research and scientific papers

Heterocyclic inhibitors of farnesyl protein transferase

Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein:, A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or substituted phenyl;, G1 is S or O;, G2 is H, -C(O)OH, -C(O)NH2, 5-tetrazolyl, -C(O)N(R7)OH or -CH2OH;, X is O or R8N;, Y and Z are each independently -CH2- or -C(O)-;, R1, R2, R3, R4, R5, R6 and R7 are each independently H or alkyl;, R1 may also be alkanoyl, R1 and A1 taken together may be -(CH2)m;, R8 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or -C(O)R9;, R9 is H, alkyl, phenyl, phenylalkyl, substituted phenyl or (substituted phenyl)alkyl;, m is 3 or 4;, n is 0, 1 or 2;, p is 0, 1 or 2; and, q is 0 or 1, with the proviso that when p is 0, then q is also 0.

Arylhydroxamates useful as antiallergy agents

Arylhydroxamates are provided having the structure STR1 wherein R1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkenyl, aralkyl, or STR2 wherein n is 1 to 4 and X is hydroxy, alkoxy, amino, C1 -C4 -alkylamino or C1 -C4 -dialkylamino. R2 is hydrogen or lower alkyl; and R3 is C1 -C20 alkyl or C3 -C20 alkenyl, aryl, aryl-alkyl, cycloalkyl, aryl-alkenyl, lower alkoxy, lower alkenyloxy, aryl-alkoxy or cycloalkyloxy. These compound are useful as inhibitors of Δ5 -lipoxygenase and as such are useful as antiallergy agents.