6723-30-4

Basic information

• Product Name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
• Synonyms: HYDROXYLAMINE, O-(TETRAHYDRO-2H-PYRAN-2-YL)-;O-(TETRAHYDRO-2H-PYRAN-2-YL)HYDROXYLAMINE;O-(TETRAHYDRO-PYRAN-2-YL)-HYDROXYLAMINE;O-(2H-Tetrahydropyran-2-yl)hydroxylamine;O-tertrahydroxy-pyran-2-yl-hydroxylamine;2-(Aminooxy)tetrahydro-2H-pyran;O-(oxan-2-yl)hydroxylaMine;O-(Tetrahydropyran-2-yl)-hydroxylaMine, 95+%
• CAS NO: 6723-30-4
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• EINECS: 1308068-626-2
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrans;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 6723-30-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 81 °C20 mm Hg(lit.)
• Flash Point: 180 °F
• Appearance: White/Low Melting Solid
• Density: 1.1274 (rough estimate)
• Vapor Pressure: 0.204mmHg at 25°C
• Refractive Index: 1.4206 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.28±0.20(Predicted)
• CAS DataBase Reference: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(6723-30-4)
• EPA Substance Registry System: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine(6723-30-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6723-30-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 6723-30-4 differently. You can refer to the following data:
1. O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases.
2. O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid which shows significant inhibitory activity against mycothiol S-conjugate amidase.

General Description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

InChI:InChI=1/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

Downstream Products

• 112800-52-9 2-Hydroxy-3-phenyl-N-(tetrahydro-2H-2-pyranyloxy)-2-(2-thienyl)propanamid 
• 6584-61-8 O-(tetrahydro-2-pyranyl)benzohydroxamic acid 
• 76440-71-6 2-Hydroxy-N-(tetrahydro-2H-2-pyranyloxy)phenylacetamid 
• 76440-77-2 2-Hydroxy-2,2-diphenyl-N-(tetrahydro-2H-2-pyranyloxy)-acetamid 
• 958255-24-8 (2E)-3-(4-hydroxyphenyl)-2-[(oxan-2-yloxy)imino]propanoic acid 
• 1035211-61-0 4-(4-benzenesulfonylamino-phenyl)-N-(tetrahydro-pyran-2-yloxy)-butyramide 
• 688045-11-6 N-(tetrahydro-pyran-2-yloxy)-3-[4-(toluene-4-sulfonylamino)-phenyl]-acrylamide 
• 313255-15-1 (2R,3R)-3-Hydroxy-4-methyl-2-(4-methyl-cyclohexylmethyl)-pentanoic acid (tetrahydro-pyran-2-yloxy)-amide 
• 212610-25-8 (2R,3R)-2-cyclohexylmethyl-3-hydroxyhexanoic acid 2-tetrahydropyranyloxyamide 

Relevant articles and documents

Heterocyclic inhibitors of farnesyl protein transferase

Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein:, A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or substituted phenyl;, G1 is S or O;, G2 is H, -C(O)OH, -C(O)NH2, 5-tetrazolyl, -C(O)N(R7)OH or -CH2OH;, X is O or R8N;, Y and Z are each independently -CH2- or -C(O)-;, R1, R2, R3, R4, R5, R6 and R7 are each independently H or alkyl;, R1 may also be alkanoyl, R1 and A1 taken together may be -(CH2)m;, R8 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or -C(O)R9;, R9 is H, alkyl, phenyl, phenylalkyl, substituted phenyl or (substituted phenyl)alkyl;, m is 3 or 4;, n is 0, 1 or 2;, p is 0, 1 or 2; and, q is 0 or 1, with the proviso that when p is 0, then q is also 0.