- Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei
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Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological
- Festa, Carmen,De Marino, Simona,Sepe, Valentina,Monti, Maria Chiara,Luciano, Paolo,D'Auria, Maria Valeria,Débitus, Cecile,Bucci, Mariarosaria,Vellecco, Valentina,Zampella, Angela
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experimental part
p. 10424 - 10429
(2010/03/04)
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- Isolation and structures of nostopeptolides A1, A2 and A3 from the cyanobacterium Nostoc sp. GSV224
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The isolation and total structure determinations of nostopeptolides A1 (1), A2 (2) and A3 (3) are described. These cyclic depsipeptides, which are devoid of cytotoxic, antifungal and inhibition of protease activities, are characteristic constituents of the cryptophycin-producing cyanobacterium Nostoc sp. GSV224. Structure elucidation by NMR analysis was made more challenging by the existence of each nostopeptolide in three conformations. One-dimensional TOCSY experiments proved to be very useful in isolating and identifying the nine amino acid residues and the butyryl group in each compound. The absolute stereochemistries of 1-3 were determined by comparing the amino acids in the acid hydrolyzates directly with authentic standards. (C) 2000 Elsevier Science Ltd.
- Golakoti, Trimurtulu,Yoshida, Wesley Y.,Chaganty, Sreedhara,Moore, Richard E.
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p. 9093 - 9102
(2007/10/03)
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- Structure of a Peptidal Antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson
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The peptide antibiotic P168 contained a new amino acid, (2S,4S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (6) and an amine, (S)-N1,N1-dimethylpropane-1,2-diamine (4) along with other unusual amino acids.The structure of the peptide was determined as (I) by in-beam mass spectrometry.
- Isogai, Akira,Suzuki, Akinori,Tamura, Saburo,Higashikawa, Shizuo,Kuyama, Shimpei
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p. 1405 - 1411
(2007/10/02)
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- Structure of Leucinostatin A, New Peptide Antibiotic from Paecilomyces lilacinus A-267
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A new antibiotic leucinostatin A was isolated from the culture filtrate of Paecilomyces lilacinus A-267 and its structure was elucidated by mass spectrometric and degradative methods.
- Mori, Yuji,Tsuboi, Makoto,Suzuki, Makoto,Fukushima, Kazutaka,Arai, Tadashi
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The Hofmann-Loeffler-Freytag reaction, carried out by irradiation in sulphuric acid of N-chloro-l-amino-acids 3a-d, gives δ-chlorinated compounds which can be cyclized to l-prolines 4a-e. This convenient synthesis does not affect the asymmetric centres of
- Titouani, S.Lafquih,Lavergne,Viallefont,Jacquier
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p. 2961 - 2965
(2007/10/02)
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