6734-41-4

Usage

Uses

Used in Pharmaceutical Applications:
(4S)-4-METHYL-L-PROLINE is used as a building block in the synthesis of proteins for various pharmaceutical applications, leveraging its unique stereochemistry to create novel therapeutic agents.
Used in Drug Design and Development:
(4S)-4-METHYL-L-PROLINE is utilized as a key component in the design and development of new drugs, particularly in the context of its potential antifungal and antibacterial properties, which can be harnessed to create effective treatments against infections.
Used in Medicinal Chemistry Research:
(4S)-4-METHYL-L-PROLINE is employed as a subject of study in medicinal chemistry, where its unique properties are explored to understand its role in biological processes and to identify new avenues for therapeutic intervention.

InChI:InChI=1/C6H11NO2/c1-4-2-5(6(8)9)7-3-4/h4-5,7H,2-3H2,1H3,(H,8,9)/t4-,5-/m0/s1

Upstream product

• 77120-56-0 C₈H₁₆ClNO₂ 
• 76600-38-9 P₁₆₈ 
• 82111-44-2 leucinostatin A 

Relevant academic research and scientific papers

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological

Isolation and structures of nostopeptolides A1, A2 and A3 from the cyanobacterium Nostoc sp. GSV224

The isolation and total structure determinations of nostopeptolides A1 (1), A2 (2) and A3 (3) are described. These cyclic depsipeptides, which are devoid of cytotoxic, antifungal and inhibition of protease activities, are characteristic constituents of the cryptophycin-producing cyanobacterium Nostoc sp. GSV224. Structure elucidation by NMR analysis was made more challenging by the existence of each nostopeptolide in three conformations. One-dimensional TOCSY experiments proved to be very useful in isolating and identifying the nine amino acid residues and the butyryl group in each compound. The absolute stereochemistries of 1-3 were determined by comparing the amino acids in the acid hydrolyzates directly with authentic standards. (C) 2000 Elsevier Science Ltd.

Structure of a Peptidal Antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson

The peptide antibiotic P168 contained a new amino acid, (2S,4S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (6) and an amine, (S)-N1,N1-dimethylpropane-1,2-diamine (4) along with other unusual amino acids.The structure of the peptide was determined as (I) by in-beam mass spectrometry.

Structure of Leucinostatin A, New Peptide Antibiotic from Paecilomyces lilacinus A-267

A new antibiotic leucinostatin A was isolated from the culture filtrate of Paecilomyces lilacinus A-267 and its structure was elucidated by mass spectrometric and degradative methods.