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675-12-7

4-Amino-2,6-Difluoropyrimidine is a chemical compound with the molecular formula C4H3F2N3. It belongs to the class of pyrimidines, which are aromatic heterocyclic organic compounds akin to pyridine and are integral parts of nucleotides. The presence of two fluorine atoms endows this molecule with distinctive chemical characteristics, predominantly affecting its reactivity and stability. Although structurally simple, 4-Amino-2,6-Difluoropyrimidine holds potential applications in the pharmaceutical sector due to the notable bioactivity of fluorinated pyrimidines, especially as synthetic precursors for a range of drugs. Additionally, it is valuable for chemical research, particularly in the realms of organic synthesis and fluorine chemistry.

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  • 675-12-7 Structure

  • Basic information

    1. Product Name: 4-AMINO-2,6-DIFLUOROPYRIMIDINE
    2. Synonyms: 4-AMINO-2,6-DIFLUOROPYRIMIDINE;4-Pyrimidinamine, 2,6-difluoro- (9CI);6-Amino-2,4-difluoropyrimidine;2,6-DifluoropyriMidin-4-aMine
    3. CAS NO:675-12-7
    4. Molecular Formula: C4H3F2N3
    5. Molecular Weight: 131.08
    6. EINECS: N/A
    7. Product Categories: PYRIMIDINE;Heterocyclic Compounds
    8. Mol File: 675-12-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 332.2 °C at 760 mmHg
    3. Flash Point: 154.7 °C
    4. Appearance: /
    5. Density: 1.513±0.06 g/cm3 (20 ºC 760 Torr)
    6. Vapor Pressure: 0.000148mmHg at 25°C
    7. Refractive Index: 1.527
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. PKA: 0.02±0.10(Predicted)
    11. CAS DataBase Reference: 4-AMINO-2,6-DIFLUOROPYRIMIDINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-AMINO-2,6-DIFLUOROPYRIMIDINE(675-12-7)
    13. EPA Substance Registry System: 4-AMINO-2,6-DIFLUOROPYRIMIDINE(675-12-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 675-12-7(Hazardous Substances Data)

675-12-7 Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2,6-Difluoropyrimidine is utilized as a synthetic precursor for the development of various drugs, capitalizing on the bioactivity of fluorinated pyrimidines. Its unique chemical properties make it a valuable component in the synthesis of pharmaceutical compounds.
Used in Chemical Research:
In the field of chemical research, 4-Amino-2,6-Difluoropyrimidine serves as a key compound for studies in organic synthesis and fluorine chemistry. Its distinctive properties allow for exploration of new reaction pathways and the creation of novel chemical entities.

Check Digit Verification of cas no

The CAS Registry Mumber 675-12-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,7 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 675-12:
(5*6)+(4*7)+(3*5)+(2*1)+(1*2)=77
77 % 10 = 7
So 675-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H3F2N3/c5-2-1-3(7)9-4(6)8-2/h1H,(H2,7,8,9)

675-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-Difluoropyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names 2,6-difluoropyrimidin-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:675-12-7 SDS

675-12-7Relevant articles and documents

2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles

Delia, Thomas J.,Anderson, Dennis P.,Schomaker, Jennifer M.

, p. 991 - 993 (2004)

In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.

MECHANISMS FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 6. INVESTIGATIONS INTO THE ACTIVATING EFFECT OF ORTHO-FLUORINE IN NUCLEOPHILIC AROMATIC SUBSTITUTION

Chambers, Richard D.,Seabury, Mark J.,Williams, D. Lyn H.,Hughes, Nigel

, p. 255 - 258 (2007/10/02)

Separate activating effects for ortho- and meta- fluorine, on nucleophilic aromatic substitution, are determinated for pyrimidine and pyridine systems.Comparisons confirm the importance of ion-dipole interactions for activation by ortho-fluorine.The effects of ortho-fluorine on anionic ?-complexes are also discussed.

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