676348-35-9Relevant articles and documents
K2S2O8-promoted radical trifluoromethylthiolation/spirocyclization for the synthesis of SCF3?featured spiro[5,5]trienones
Dai, Peng,Li, Bing,Shen, Liu-Yu,Sun, Yu,Wang, Yu-Qi,Yang, Wen-Chao
supporting information, (2022/01/24)
A direct and efficient strategy for the trifluoromethylthiolation and dearomatization of biaryl ynones with stable and readily available AgSCF3 has been developed. The reaction occurs smoothly in the presence of K2S2O8 via a 6-exo-trig radical cyclization, providing a variety of SCF3-containing spiro [5,5]trienones in good yields.
Novel Biphenyl Derivative Compound and Use Thereof
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Paragraph 0065-0067, (2021/07/17)
The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increas
Electrochemical Trifluoromethylthiolation and Spirocyclization of Alkynes with AgSCF3: Access to SCF3-Containing Spiro[5,5]trienones
Yang, Wen-Chao,Zhang, Ming-Ming,Sun, Yu,Chen, Cai-Yun,Wang, Lei
supporting information, p. 6691 - 6696 (2021/09/08)
A novel and efficient strategy for trifluoromethylthiolation and dearomatization of activated alkynes with stable and readily available AgSCF3 has been developed. Reported herein is the unprecedented electrochemical generation of the SCF3 radical in the absence of persulfate for the synthesis of SCF3-containing spiro[5,5]trienones in good yields via a 6-exo-trig radical cyclization.
PHARMACEUTICAL COMPOSITION, CONTAINING NM23 ACTIVATOR, FOR INHIBITING CANCER METASTASIS
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Paragraph 0048-0049, (2020/03/17)
The present disclosure relates to a pharmaceutical composition for suppressing cancer metastasis containing, as an active ingredient, an activator compound of the cancer metastasis inhibitor Nm23, a stereoisomer thereof, or a pharmaceutically acceptable s
Atom-economic threefold cross-couplings of triarylbismuth reagents with 2-halobenzaldehydes and pot-economic in situ Wittig functionalizations with phosphonium salts
Rao, Maddali L. N.,Dhanorkar, Ritesh J.
, p. 63792 - 63806 (2015/02/19)
In this paper we report an efficient pot-economic methodology for the synthesis of ortho-olefinated biaryls. This has been achieved through an atom-economic threefold cross-coupling of triarylbismuth reagents with 2-halobenzaldehydes followed by pot-economic in situ Wittig olefination. The overall process is a pot-economic straightforward synthesis of ortho-olefinated biaryls from 2-halobenzaldehydes, triarylbismuth reagents and phosphonium salts. This pot-economic approach was applied to the formal synthesis of medicinally important Eupomatilone-6.
A new synthetic approach to 6-unsubstituted phenanthridine and phenanthridine-like compounds under mild and metal-free conditions
Tummatorn, Jumreang,Krajangsri, Suppachai,Norseeda, Krissada,Thongsornkleeb, Charnsak,Ruchirawat, Somsak
supporting information, p. 5077 - 5081 (2014/07/08)
A new and mild synthetic approach for the synthesis of 6-unsubstituted phenanthridine and phenanthridine-like compounds under metal-free conditions at room temperature has been developed. The strategy involved a tandem azide rearrangement/intramolecular annulation and oxidation reactions of biarylmethyl azide precursors to obtain the desired products in up to 99% yields with high regioselectivity.
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
Chosson, Elizabeth,Santoro, Francesca,Rochais, Christophe,Santos, Jana Sopkova-De Oliveira,Legay, Rémi,Thoret, Sylviane,Cresteil, Thierry,Sinicropi, Maria Stefania,Besson, Thierry,Dallemagne, Patrick
experimental part, p. 2614 - 2623 (2012/06/01)
The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β- phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory ef
One-Pot Zn/CuI/TFA-catalyzed domino three-component-carbocyclization reaction involving Biphenyl-2-carbaldehydes/Alkynes/Piperidine: Allenes-mediated construction of phenanthrenes
Saifuddin, Mohammad,Agarwal, Piyush K.,Kundu, Bijoy
experimental part, p. 10122 - 10128 (2012/02/05)
A one-pot protocol involving Zn/CuI/TFA-catalyzed domino three-component and subsequent carbocyclization reactions is described. The reaction proceeds via formation of propargyl amines from biphenyl-2-carbaldehydes/terminal alkynes/piperidine followed by