676372-30-8Relevant articles and documents
AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS
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Page/Page column 746, (2019/08/12)
The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.
Synthesis of 1-benzyl-8,9-dihydroimidazo[4,5-c]pyrrolo[3,2-g]quinolin-4(5H) -one via palladium-catalyzed intramolecular arylation
Delest, Bruno,Tisserand, Jean-Yves,Robert, Jean-Michel,Nourrisson, Marie-Renée,Pinson, Patricia,Duflos, Muriel,Le Baut, Guillaume,Renard, Pierre,Pfeiffer, Bruno
, p. 6079 - 6083 (2007/10/03)
The synthesis of a novel tetracyclic structure, 8,9-dihydroimidazo[4,5-c] pyrrolo[3,2-g]quinolin-4(5H)-one, has been achieved by a convergent pathway. Coupling of the weakly nucleophilic hindered aromatic amine with 1-benzylimidazole-4-carboxylic acid, 7, afforded the corresponding amide 9 using a DCP/DMF complex; subsequent Heck-type arylation leading to desired tetracyclic molecule imidazo[4,5-c]-pyrrolo[3,2-g]quinolin-4(5H)-one.