cas 676596-61-5, 3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester | Articles data ｜lookchem

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676596-61-5

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9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) inhibitor activating pancreatic β cell protection and replication
Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote β cell protection and re
Stukenbrock, Hendrik,Mussmann, Rainer,Geese, Marcus,Ferandin, Yoan,Lozach, Olivier,Lemcke, Thomas,Kegel, Simone,Lomow, Alexander,Burk, Ulrike,Dohrmann, Cord,Meijer, Laurent,Austen, Matthias,Kunick, Conrad
p. 2196 - 2207
(2008/12/22)

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β
Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3β versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3β selectivity of 1-azakenpaullone compared to other paullone derivatives.
Kunick, Conrad,Lauenroth, Kathrin,Leost, Maryse,Meijer, Laurent,Lemcke, Thomas
p. 413 - 416
(2007/10/03)

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Chemical Properties

Boiling Point: 500.887oC at 760 mmHg
Flash Point:256.727oC
Density: 1.228g/cm3
Solubility:Methanol
Vapor Pressure: 0mmHg at 25°C
PSA: 98.08000
LogP: 2.18960

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