676596-61-5 Usage
Uses
Used in Pharmaceutical Industry:
3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester is used as a synthetic intermediate for the synthesis of 1-Azakenpaullone and other Kenpaullone derivatives. These compounds have potential applications in the development of new pharmaceuticals, particularly in the treatment of various diseases and disorders.
Used in Organic Chemistry Research:
In the field of organic chemistry, 3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester serves as a valuable intermediate for the synthesis of complex organic molecules. Its unique structure allows for further functionalization and modification, making it a versatile building block for the development of novel compounds with potential applications in various industries.
Used in Drug Discovery and Development:
3-[(4-Ethoxy-1,4-dioxobutyl)amino]-2-pyridinecarboxylic Acid Ethyl Ester is utilized in drug discovery and development processes, where it contributes to the synthesis of new drug candidates. Its role in the preparation of Kenpaullone derivatives highlights its potential in the development of innovative therapeutic agents with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 676596-61-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,6,5,9 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 676596-61:
(8*6)+(7*7)+(6*6)+(5*5)+(4*9)+(3*6)+(2*6)+(1*1)=225
225 % 10 = 5
So 676596-61-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H18N2O5/c1-3-20-12(18)8-7-11(17)16-10-6-5-9-15-13(10)14(19)21-4-2/h5-6,9H,3-4,7-8H2,1-2H3,(H,16,17)
676596-61-5Relevant academic research and scientific papers
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) inhibitor activating pancreatic β cell protection and replication
Stukenbrock, Hendrik,Mussmann, Rainer,Geese, Marcus,Ferandin, Yoan,Lozach, Olivier,Lemcke, Thomas,Kegel, Simone,Lomow, Alexander,Burk, Ulrike,Dohrmann, Cord,Meijer, Laurent,Austen, Matthias,Kunick, Conrad
, p. 2196 - 2207 (2008/12/22)
Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic β cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone promote β cell protection and re
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β
Kunick, Conrad,Lauenroth, Kathrin,Leost, Maryse,Meijer, Laurent,Lemcke, Thomas
, p. 413 - 416 (2007/10/03)
Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3β versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3β selectivity of 1-azakenpaullone compared to other paullone derivatives.
