- Ruthenium-catalyzed enantioselective C-H functionalization: A practical access to optically active indoline derivatives
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Ru(II)-catalyzed enantioselective C-H activation/hydroarylation has been developed for the first time, allowing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation. Commercially available Ru(II) arene complexes and chiral α-methylamines were employed as highly enantioselective catalysts. Based on a sterically rigidified chiral transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee. Further transformation of the resulting 4-formylindoline enables access to an optically active tricyclic compound that is of potential biological and pharmaceutical interest.
- Li, Zhong-Yuan,Lakmal, Hetti Handi Chaminda,Qian, Xiaolin,Zhu, Zhenyu,Donnadieu, Bruno,McClain, Sarah J.,Xu, Xue,Cui, Xin
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supporting information
p. 15730 - 15736
(2019/10/11)
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- Catalytic synthesis of functional silicon-stereogenic silanes through Candida antarctica lipase B catalyzed remote desymmetrization of silicon-centered diols
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A series of silicon-containing diols are synthesized and used in lipase-catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon-stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL-B (up to 90:10 er). Remote desymmetrization: A series of silicon-containing diols are synthesized and used in Candida antarctica lipase B (CAL-B)-catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon-stereogenic organosilicon compounds. Copyright
- Lu, Xing,Li, Li,Yang, Wei,Jiang, Kezhi,Yang, Ke-Fang,Zheng, Zhan-Jiang,Xu, Li-Wen
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supporting information
p. 5814 - 5819
(2013/09/23)
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- Novel Sulfonaminoquinoline Hepcidin Antagonists
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The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
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Page/Page column 167
(2012/09/05)
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- SUBSTITUTED BENZYL AMINE COMPOUNDS
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Certain substituted benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
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Page/Page column 62
(2008/06/13)
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- TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS
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The invention includes tetrahydroquinoline and related compounds of formula (I), and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
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