679840-30-3

Basic information

• Product Name: 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE
• Synonyms: RARECHEM AL BP 0325;1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE;2-(5-Bromo-2-fluorophenyl)-1,3-dioxolane
• CAS NO: 679840-30-3
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.06
• Mol File: 679840-30-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 259.993°C at 760 mmHg
• Flash Point: 133.275°C
• Appearance: /
• Density: 1.59g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE(679840-30-3)
• EPA Substance Registry System: 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE(679840-30-3)

Safety Data

• Hazardous Substances Data: 679840-30-3(Hazardous Substances Data)

Usage

General Description

1-Bromo-3-(1,3-dioxolan-2-yl)-4-fluorobenzene, also known as 1-bromo-4-fluoro-3-(1,3-dioxolan-2-yl)benzene, is a chemical compound with the molecular formula C8H7BrFO2. It is a brominated fluorobenzene derivative that contains a dioxolane ring. 1-BROMO-3-(1,3-DIOXOLAN-2-YL)-4-FLUOROBENZENE is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of various organic compounds. It has also been studied for its potential biological and medicinal properties. However, it is important to handle this chemical with caution due to its potential hazards and harmful effects on human health and the environment.

InChI:InChI=1/C9H8BrFO2/c10-6-1-2-8(11)7(5-6)9-12-3-4-13-9/h1-2,5,9H,3-4H2

Upstream product

• 107-21-1 ethylene glycol 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 1500116-41-5 (methyl(phenyl)silanediyl)bis(2-fluoro-5,1-phenylene)dimethanol 
• 1500116-43-7 (phenyl(vinyl)silanediyl)bis(2-fluoro-5,1-phenylene)dimethanol 
• 310894-53-2 5-methylthiobenzo[b]thiophene-2-carboxylic acid 
• 1394085-43-8 (3-[1,3]dioxolan-2-yl-4-fluoro-phenyl)-(8-nitro-quinolin-7-yl)-methanol 
• 310894-51-0 methyl 5-methylthio benzo[b]thiophene-2-carboxylate 

Relevant articles and documents

Ruthenium-catalyzed enantioselective C-H functionalization: A practical access to optically active indoline derivatives

Ru(II)-catalyzed enantioselective C-H activation/hydroarylation has been developed for the first time, allowing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation. Commercially available Ru(II) arene complexes and chiral α-methylamines were employed as highly enantioselective catalysts. Based on a sterically rigidified chiral transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee. Further transformation of the resulting 4-formylindoline enables access to an optically active tricyclic compound that is of potential biological and pharmaceutical interest.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS

The invention includes tetrahydroquinoline and related compounds of formula (I), and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.