680584-61-6Relevant articles and documents
Synthesis of gibberellic acid derivatives and their effects on plant growth
Tian, Hao,Xu, Yiren,Liu, Shaojin,Jin, Dingsha,Zhang, Jianjun,Duan, Liusheng,Tan, Weiming
supporting information, (2017/06/08)
A series of novel C-3-OH substituted gibberellin derivatives bearing an amide group were designed and synthesized from the natural product gibberellic acid (GA3). Their activities on the plant growth regulation of rice and Arabidopsis were evaluated in vivo. Among these compounds, 10d and 10f exhibited appreciable inhibitory activities on rice (48.6% at 100 μmol/L) and Arabidopsis (41.4% at 100mol/L), respectively. These results provide new insights into the design and synthesis of potential plant growth regulators.
Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: A novel entry into the 1,2,4-triazine core
Lukin, Alexey,Vedekhina, Tatiana,Tovpeko, Dmitry,Zhurilo, Nikolay,Krasavin, Mikhail
, p. 57956 - 57959 (2016/07/07)
Hydrohydrazination of a variety of propargylamides with BocNHNH2 under Zn(OTf)2 catalysis, unexpectedly, gave dihydro-1,2,4-triazines with a loss of the protecting group. The initial products can be efficiently aromatized in situ wit
Metal-coordinated water-soluble cavitands act as C - H oxidation catalysts
Djernes, Katherine E.,Moshe, Orly,Mettry, Magi,Richards, Donald D.,Hooley, Richard J.
supporting information; experimental part, p. 788 - 791 (2012/05/04)
Cavitands can be smoothly derivatized by CuAAC chemistry to incorporate ligand species at the upper rim. These species can coordinate metal species in a number of different conformations, leading to self-assembly. The metal-coordination confers water solu
Surprising alteration of antibacterial activity of 5″-modified neomycin against resistant bacteria
Zhang, Jianjun,Chiang, Fang-I.,Wu, Long,Czyryca, Przemyslaw Greg,Li, Ding,Chang, Cheng-Wei Tom
experimental part, p. 7563 - 7573 (2009/12/07)
A facile synthetic protocol for the production of neomycin B derivatives with various modifications at the 5″ position has been developed. The structural activity relationship (SAR) against aminoglycoside resistant bacteria equipped with various aminoglycoside-modifying enzymes (AMEs) was investigated. Enzymatic and molecular modeling studies reveal that the superb substrate promiscuity of AMEs allows the resistant bacteria to cope with diverse structural modifications despite the observation that several derivatives show enhanced antibacterial activity compared to the parent neomycin. Surprisingly, when testing synthetic neomycin derivatives against other human pathogens, two leads exhibit prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) that are known to exert a high level of resistance against clinically used aminoglycosides. These findings can be extremely useful in developing new aminoglycoside antibiotics against resistant bacteria. Our result also suggests that new biological and antimicrobial activities can be obtained by chemical modifications of old drugs.