681128-50-7

Basic information

• Product Name: (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid,4-fluoro-,1-(1,1-dimethylethyl) ester,(2R,4S)-;(2R,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylic acid;(2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid;(4S)-1-Boc-4-fluoro-D-proline
• CAS NO: 681128-50-7
• Molecular Formula: C₁₀H₁₆FNO₄
• Molecular Weight: 233.2367432
• Mol File: 681128-50-7.mol

Chemical Properties

• Boiling Point: 346.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.53±0.40(Predicted)
• CAS DataBase Reference: (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid(681128-50-7)
• EPA Substance Registry System: (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid(681128-50-7)

Safety Data

• Hazardous Substances Data: 681128-50-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
(2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid is used as a potential building block for the development of new drugs. Its fluorine atom and carboxylic acid functional group can be exploited to create novel molecular entities with specific biological activities, addressing unmet medical needs.
Used in Biochemical Research:
In biochemical research, (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid can be employed as a synthetic intermediate or a probe molecule to study enzyme mechanisms, protein-ligand interactions, or other biological processes. Its unique structure may provide insights into the molecular basis of various biological phenomena.
Used in Organic Synthesis:
(2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid is used as a synthetic intermediate in organic chemistry. The tert-butoxycarbonyl group can be selectively removed under mild conditions, revealing the reactive functional groups for further chemical transformations. This property makes it a valuable component in the synthesis of complex organic molecules and natural products.
Used in Drug Delivery Systems:
(2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid can be utilized in the design of drug delivery systems, where its carboxylic acid functional group can be conjugated to various carriers, such as nanoparticles or polymers. This allows for targeted drug delivery and controlled release, improving the therapeutic efficacy and reducing side effects of the drug molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 913820-71-0 (2R,4S)-4-fluoropyrrolidine-2-carboxylic acid 
• 647857-39-4 1-(tert-butyl) 2-methyl (2R,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 
• 2584-71-6 cis-hydroxy-D-proline 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 

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