68157-60-8

Basic information

• Product Name: Forchlorfenuron
• Synonyms: CPPU;KT-30;FORCHLORFENURON;4-CPPU;1-(2-CHLORO-4-PYRIDYL)-3-PHENYLUREA;1-(2-CHLOROPYRIDIN-4-YL)-3-PHENYL-UREA;N-(2-CHLORO-4-PYRIDYL)-N'-PHENYLUREA;phenyl-n'-(2-chloro-4-pyridyl)urea
• CAS NO: 68157-60-8
• Molecular Formula: C12H10ClN3O
• Molecular Weight: 247.68
• EINECS: 1806241-263-5
• Product Categories: FINE Chemical & INTERMEDIATES;PLANT GROWTH REGULATOR;Biochemistry;Chloropyridines;Cytokinins;Halopyridines;Plant Growth Regulators;Plant Hormones;Agro-Products;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;plantgrowth
• Mol File: 68157-60-8.mol

Chemical Properties

• Melting Point: 170-172°C
• Boiling Point: 308.418 °C at 760 mmHg
• Flash Point: 140.326 °C
• Appearance: white crystals
• Density: 1.415 g/cm³
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMSO or Ethanol
• PKA: 12.55±0.70(Predicted)
• Stability: Stable for 1 year from date ofpurchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: Forchlorfenuron(CAS DataBase Reference)
• NIST Chemistry Reference: Forchlorfenuron(68157-60-8)
• EPA Substance Registry System: Forchlorfenuron(68157-60-8)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37-51/53-40
• Safety Statements: 26-36-61-46-36/37
• RIDADR: UN3077 9/PG 3
• WGK Germany: 3
• RTECS: YS7182500
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 68157-60-8(Hazardous Substances Data)

Usage

Uses

Used in Plant Growth Regulation:
Forchlorfenuron is used as a plant growth regulator (PGR) in horticulture. It is commonly used to stimulate the growth of kiwi fruit and grapes, enhancing their yield and quality.
Used in Scientific Research:
Forchlorfenuron is utilized as a research tool to investigate the physiological role of septin and its complexes, providing valuable insights into the mechanisms of cell division and migration.

Trade name

CN-11-3183; KT-30?; SKW 20010

Potential Exposure

Phenylurea/substituted urea plant growth regulator widely used in agriculture on fruits to increase their size, to promote cell division, and to improve the quality and the yield of fruits, especially table grapes, grape raisins, and kiwi fruit. In some parts of California, forchlorfenuron is reputed to double the size of Thompson seedless grapes and delay crop maturity up to several weeks.

Incompatibilities

May react with strong oxidizers such as chlorates, peroxides, nitrates, etc. Dust may form explosive mixture with air.

Waste Disposal

Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. If this material cannot be disposed of according to label instruc tions, it may be dissolved or mixed with a combustible sol vent and burned in a chemical incinerator equipped with an afterburner and scrubber. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers.

References

1) Hu et al. (2008), Forchlorfenuron alters mammalian septin assembly, organization, and dynamics; J. Biol. Chem., 283 29563 2) DeMay et al. (2010), Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton; Cytoskeleton, 67 383 3) Wasik et al. (2012), Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking; Mol. Biol. Cell, 23 3370 4) Vardi-Oknin et al. (2013), Forchlorfenuron disrupts SEPT9_i1 filaments and inhibits HIF-1; PLoS One, 8(8) e73179

Synthetic route

2,4-dichloropyridine (26452-80-2) + phenyl carbamate (64-10-8) → N-(4-chloropyridin-2-yl)-N'-phenylurea + N-(2-chloro-4-pyridyl)-N'-phenylurea (68157-60-8)

Conditions	Yield
With 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate; palladium diacetate In 1,4-dioxane at 100℃; for 3.5h;	A 80% B 6%

N-(2-chloro-4-pyridyl)-N'-phenylurea (68157-60-8) → 3-(2-chloropyridin-4-yl)-5-methyl-1-phenyl-1,3,5-triazin-2-one

Conditions	Yield
With formaldehyd; methylamine In methanol

N-(2-chloro-4-pyridyl)-N'-phenylurea (68157-60-8) → Reaxys ID: 31949060

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorosulfonic acid / dichloromethane / 3 h / 20 - 40 °C View Scheme

N-(2-chloro-4-pyridyl)-N'-phenylurea (68157-60-8) → C12H10ClN3O4S

Conditions	Yield
With chlorosulfonic acid In dichloromethane at 20 - 40℃; for 3h;

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 64-10-8 phenyl carbamate 

Downstream Products

• 14432-12-3 4-Amino-2-chloropyridine 
• 67-56-1 methanol 
• 62-53-3 aniline 

Relevant articles and documents

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