- Nonsteroidal Antiinflammatory Agents. 14. Synthesis and Pharmacological Profile of 6-Chloro-5-(cyclopentylmethyl)indan-1-carboxylic Acid
-
The preparation of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid is described.This acid has good antiinlammatory and analgesic activities without producing irritation in the gastrointestinal tract up to the highest tested dose.
- Boettcher, Irmgard,Elger, Walter,Kirsch, Gerald,Siegmund, Fred,Wachtel, Helmut
-
-
Read Online
- Novel phenylacetic acid derivatives
-
Phenylacetic acid derivatives of the formula STR1 wherein n is an integer of 2 to 5; STR2 R1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R2 and R3 each independently is hydrogen or lower alkyl; or together form an ethylene group; X1 represents two hydrogen atoms or an oxo group; and Y1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl; and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.
- -
-
-
- Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use
-
Compounds of Formula I STR1 wherein R1 is the residue of an antiphlogistically effective carboxylic acid of the formula R1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.
- -
-
-