683242-79-7

Basic information

• Product Name: 2,3-Diamino-6-trifluoromethylpyridine
• Synonyms: 2,3-Diamino-6-trifluoromethylpyridine;6-(TrifluoroMethyl)pyridine-2,3-diaMine;6-(trifluoromethyl)-2,3-pyridinediamine
• CAS NO: 683242-79-7
• Molecular Formula: C6H6F3N3
• Molecular Weight: 177.1271496
• Mol File: 683242-79-7.mol

Chemical Properties

• Boiling Point: 281.262°C at 760 mmHg
• Flash Point: 123.903°C
• Appearance: /
• Density: 1.467g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.06±0.50(Predicted)
• CAS DataBase Reference: 2,3-Diamino-6-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Diamino-6-trifluoromethylpyridine(683242-79-7)
• EPA Substance Registry System: 2,3-Diamino-6-trifluoromethylpyridine(683242-79-7)

Safety Data

• Hazardous Substances Data: 683242-79-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,3-Diamino-6-trifluoromethylpyridine is used as a chemical intermediate for the synthesis of various complex organic compounds. Its unique structure and functional groups make it a valuable building block in the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,3-Diamino-6-trifluoromethylpyridine is employed as a key intermediate in the synthesis of new drug candidates. Its presence in the molecular structure can impart specific biological activities, making it a crucial component in the development of novel therapeutic agents. 2,3-Diamino-6-trifluoromethylpyridine's versatility in chemical reactions allows for the exploration of different drug design strategies and the creation of potential treatments for various diseases and conditions.

InChI:InChI=1/C6H6F3N3/c7-6(8,9)4-2-1-3(10)5(11)12-4/h1-2H,10H2,(H2,11,12)

Upstream product

• 683242-78-6 N²-(4-methoxybenzyl)-6-trifluoromethylpyridine-2,3-diamine 
• 34486-24-3 2-amino-6-(trifluoromethyl)pyridine 
• 893444-21-8 3-nitro-6-(trifluoromethyl)pyridin-2-amine 
• 117519-09-2 3-amino-2-chloro-6-(trifluoromethyl)pyridine 

Downstream Products

• 1375702-96-7 C₂HF₃O₂*C₂₆H₂₄F₄N₆O₂ 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

IMIDAZOLE DERIVATIVES

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PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

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The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS

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