117519-09-2Relevant articles and documents
COMPOUNDS AND COMPOSITIONS AS TLR-7 ACTIVITY MODULATORS
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Page/Page column 102, (2011/06/11)
The invention provides compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
PROCESS FOR PRODUCTION OF 3-AMINO-2-CHLORO-6- TRIFLUOROMETHYLPYRIDINE
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Page/Page column 5, (2010/12/01)
To provide a process for efficiently producing 3-amino-2-chloro-6-trifluoromethylpyridine. To provide a process for producing 3-amino-2-chloro-6-trifluoromethylpyridine, comprising reacting 2-chloro-6-trifluoromethylnicotinamide with a hypochlorite in the presence of a solvent and a base, and a process for efficiently producing 2-chloro-6-trifluoromethylnicotinamide as the starting material from 2-chloro-6-trifluoromethylnicotinic acid or 2-hydroxy-6-trifluoromethylnicotinamide.
NOVEL PHARMACEUTICALS
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Page/Page column 71, (2010/11/28)
The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.