- Using an asymmetric flow reactor sharples
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PROBLEM TO BE SOLVED: To provide a method for efficiently progressing a Sharpless asymmetric epoxidation even without adding molecular sieves. SOLUTION: The method for producing an optically active epoxyalcohol compound includes mixing an allyl alcohol compound, a titanium tetraalkoxide in a catalytic amount, an optically active tartaric acid ester in a catalytic amount, and an oxidizing agent, in a solvent by using a flow-type reactor (flow reactor). The oxidizing agent is preferably tert-butyl hydroperoxide or cumene hydroperoxide. COPYRIGHT: (C)2013,JPOandINPIT
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Paragraph 0046
(2019/05/21)
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- 1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME
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The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula -CH2RA; X is a halogen atom or a group of the formula -S(O)n-R1) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.
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Page/Page column 47-48
(2010/02/12)
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