Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines
N-1-Alkylamino and N-1-alkyloxy-4-hydroxyquinolon-3-yl benzothiadiazines were synthesized and evaluated as inhibitors of genotype 1 HCV polymerase. The N-1-alkyloxy derivatives were not potent inhibitors, however N-1-alkylamino derivatives displayed compa
Pratt, John K.,Donner, Pamela,McDaniel, Keith F.,Maring, Clarence J.,Kati, Warren M.,Mo, Hongmei,Middleton, Tim,Liu, Yaya,Ng, Teresa,Xie, Qinghua,Zhang, Rong,Montgomery, Debra,Molla, Akhteruzzaman,Kempf, Dale J.,Kohlbrenner, William
p. 1577 - 1582
(2007/10/03)
Anti-infective agents
Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
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(2008/06/13)
Anti-infective agents
Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
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Page 68; 82
(2010/02/06)
Anti-infective agents
The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC
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Page/Page column 100; 101
(2010/02/08)
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