A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids
A series of diastereoisomers of β-methyl-β-phenylalanine analogues 1a?f have been prepared in enantiomerically pure form using a combination of chemo- and biocatalysis. Starting from l-threonine methyl ester 2, a range of β,β-disubstituted didehydroamino
Roff, Geoffrey J.,Lloyd, Richard C.,Turner, Nicholas J.