688798-57-4

Basic information

• Product Name: 4-[(2-Bromophenyl)sulphonyl]morpholine
• Synonyms: 4-[(2-Bromophenyl)sulphonyl]morpholine;4-(2-Bromophenylsulfonyl)morpholine;4-(2-Bromobenzenesulfonyl)morpholine
• CAS NO: 688798-57-4
• Molecular Formula: C₁₀H₁₂BrNO₃S
• Molecular Weight: 306.18
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 688798-57-4.mol

Chemical Properties

• Boiling Point: 426.224 °C at 760 mmHg
• Flash Point: 211.573 °C
• Appearance: /
• Density: 1.595 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-[(2-Bromophenyl)sulphonyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-Bromophenyl)sulphonyl]morpholine(688798-57-4)
• EPA Substance Registry System: 4-[(2-Bromophenyl)sulphonyl]morpholine(688798-57-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 688798-57-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-[(2-Bromophenyl)sulphonyl]morpholine serves as a key intermediate in the synthesis of various biologically active compounds. It is utilized as a starting material for the development of new pharmaceuticals, contributing to the creation of drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 4-[(2-Bromophenyl)sulphonyl]morpholine is employed as a precursor in the production of agrochemicals. Its role in organic synthesis allows for the preparation of compounds that can be used in pesticides, herbicides, and other agricultural chemicals to enhance crop protection and yield.
Used in Organic Synthesis:
4-[(2-Bromophenyl)sulphonyl]morpholine is also used as a versatile reagent in organic synthesis. Its unique structure facilitates a range of chemical reactions, making it an essential component in the preparation of complex organic molecules for various applications, including but not limited to, the development of new materials and the advancement of chemical research.

InChI:InChI=1/C10H12BrNO3S/c11-9-3-1-2-4-10(9)16(13,14)12-5-7-15-8-6-12/h1-4H,5-8H2

Upstream product

• 108-86-1 bromobenzene 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 110-91-8 morpholine 
• 60199-33-9 ortho-bromobenzenesulfonyl hydrazide 

Downstream Products

• 5033-21-6 4-benzenesulfonylmorpholine 
• 1610528-66-9 4-benzenesulfonyl-3,4-dihydro-2H-[1,4]oxazine 
• 1610528-67-0 1,2,4,4a-tetrahydro-3-oxa-9-thia-9a-azafluorene 9,9-dioxide 

Relevant articles and documents

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.

Cu-catalyzed aerobic oxidative synthesis of sulfonamides from sulfonyl hydrazides and amines

An environmentally friendly route for sulfonamides has been developed. The oxidative coupling of sulfonyl hydrazides and amines was catalyzed by CuBr2 to produce various sulfonamides with the water and nitrogen gas as byproducts. Preliminary experiments revealed that the sulfonyl radical is likely to be involved in the reaction mechanism.

Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines

A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.

Palladium-catalysed dehydrogenative sp3 C-H bonds functionalisation into alkenes: A direct access to N-alkenylbenzenesulfonamides

The palladium-catalysed dehydrogenation of sp3 carbon-hydrogen bonds of N-alkylbenzenesulfonamides allows a simple access to N-alkenylbenzenesulfonamides. The reaction proceeds with easily accessible catalysts, with pivalate as a base, and allo

PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.