4-(2-Bromophenylsulfonyl)morpholine

Base Information

• Chemical Name: 4-(2-Bromophenylsulfonyl)morpholine
• CAS No.: 688798-57-4
• Molecular Formula: C10H12BrNO3S
• Molecular Weight: 306.18
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20429153
• Mol file: 688798-57-4.mol

Synonyms:4-(2-BROMOPHENYLSULFONYL)MORPHOLINE;688798-57-4;4-(2-bromophenyl)sulfonylmorpholine;4-[(2-Bromophenyl)sulphonyl]morpholine;4-(2-bromobenzenesulfonyl)morpholine;SCHEMBL20627051;DTXSID20429153;MFCD09340792;AKOS008009665;4-(2-Bromobenzene-1-sulfonyl)morpholine;NCGC00181894-01;BS-23146;AB00988890-01;A866958;Z45515873

Chemical Property of 4-(2-Bromophenylsulfonyl)morpholine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 426.224 °C at 760 mmHg
• Flash Point: 211.573 °C
• PSA: 54.99000
• Density: 1.595 g/cm³
• LogP: 2.48870
• Storage Temp.: Keep Cold
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 304.97213
• Heavy Atom Count: 16
• Complexity: 321

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Bromophenylsulfonyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1S(=O)(=O)C2=CC=CC=C2Br

Technology Process of 4-(2-Bromophenylsulfonyl)morpholine

There total 5 articles about 4-(2-Bromophenylsulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + o-bromobenzenesulfonyl chloride (2905-25-1) → 4-((2-bromophenyl)sulfonyl)morpholine (688798-57-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201300795

Reference yield: 84.0%

morpholine (110-91-8,99108-56-2) + ortho-bromobenzenesulfonyl hydrazide (60199-33-9) → 4-((2-bromophenyl)sulfonyl)morpholine (688798-57-4)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In decane; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1039/c5ob02075a

Reference yield: 76.0%

→ 4-((2-bromophenyl)sulfonyl)morpholine (688798-57-4)

Guidance literature:

With copper(ll) bromide; In acetonitrile; at 50 ℃; for 12h;

upstream raw materials:

morpholine

o-bromobenzenesulfonyl chloride

bromobenzene

ortho-bromobenzenesulfonyl hydrazide

Downstream raw materials:

4-benzenesulfonylmorpholine

4-benzenesulfonyl-3,4-dihydro-2H-[1,4]oxazine

1,2,4,4a-tetrahydro-3-oxa-9-thia-9a-azafluorene 9,9-dioxide