- Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata
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A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
- Wang, Juan,Wang, Xiao-Hui,Liu, Xiao,Li, Jun,Shi, Xiao-Ping,Song, Yue-Lin,Zeng, Ke-Wu,Zhang, Le,Tu, Peng-Fei,Shi, She-Po
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supporting information
p. 3550 - 3553
(2016/08/16)
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- METHOD FOR SYNTHESIZING BETA-DICARBONYL COMPOUNDS
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A method for synthesizing beta-dicarbonyl compounds, particularly beta-diketones, from at least two carbonyl compounds, such as esters and ketones, in the presence of a strong base or a mixture of strong bases by Claisen condensation with a titer of greater than 95%. The method includes providing a synthesis reactor on which a separation column, provided with a condenser and with at least one microwave generator, is mounted; feeding a first carbonyl compound and the strong base into the synthesis reactor; heating the reactor and starting up the condenser; starting up the microwave generator(s); when the mixture is brought to a boil at total flux, feeding the second carbonyl compound into the reactor; and after a waiting time, stopping the reactor and acidifying and washing the reaction mixture.)
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Paragraph 0130; 0131; 0132; 0133
(2014/04/03)
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- Process for base-promoted condensation reactions and base reagent therefor
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A method for the preparation of 1,3-diketones is disclosed wherein the method comprises the steps of:(A) mixing an alkali metal base with a hindered alcohol in an aromatic hydrocarbon solvent;(B) boiling the mixture and azeotropically distilling water formed by the reaction between the base and the alcohol, whereby a solution of a hindered alkali metal alkoxide is formed in situ in the solvent;(C) mixing an ester with the solution of the hindered alkali metal alkoxide in the aromatic hydrocarbon solvent; and then(D) adding a ketone to the mixture.
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- Substituted oxazoles and thiazoles derivatives as hPPARγ and hPPARα activators
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The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual activators of hPPARγ and hPPAR{acute over (α)}.
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