68892-13-7Relevant articles and documents
Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata
Wang, Juan,Wang, Xiao-Hui,Liu, Xiao,Li, Jun,Shi, Xiao-Ping,Song, Yue-Lin,Zeng, Ke-Wu,Zhang, Le,Tu, Peng-Fei,Shi, She-Po
supporting information, p. 3550 - 3553 (2016/08/16)
A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity
Pistorius, Dominik,Ullrich, Angelika,Lucas, Simon,Hartmann, Rolf W.,Kazmaier, Uli,Mueller, Rolf
body text, p. 850 - 853 (2012/02/04)
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Process for base-promoted condensation reactions and base reagent therefor
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, (2008/06/13)
A method for the preparation of 1,3-diketones is disclosed wherein the method comprises the steps of:(A) mixing an alkali metal base with a hindered alcohol in an aromatic hydrocarbon solvent;(B) boiling the mixture and azeotropically distilling water formed by the reaction between the base and the alcohol, whereby a solution of a hindered alkali metal alkoxide is formed in situ in the solvent;(C) mixing an ester with the solution of the hindered alkali metal alkoxide in the aromatic hydrocarbon solvent; and then(D) adding a ketone to the mixture.