68898-75-9

Basic information

• Product Name: Formamide, N-[2-[4-(phenylmethoxy)phenyl]ethyl]-
• CAS NO: 68898-75-9
• Molecular Weight: 255.316
• Mol File: 68898-75-9.mol

Chemical Properties

• CAS DataBase Reference: Formamide, N-[2-[4-(phenylmethoxy)phenyl]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[2-[4-(phenylmethoxy)phenyl]ethyl]-(68898-75-9)
• EPA Substance Registry System: Formamide, N-[2-[4-(phenylmethoxy)phenyl]ethyl]-(68898-75-9)

Safety Data

• Hazardous Substances Data: 68898-75-9(Hazardous Substances Data)

Upstream product

• 13062-78-7 N-[2-(4-hydroxyphenyl)ethyl]formamide 
• 100-39-0 benzyl bromide 
• 51-67-2 tyrosamine 
• 60-19-5 tyramine hydrochloride 
• 100-44-7 benzyl chloride 

Downstream Products

• 244221-02-1 2-(4-benzyloxyphenyl)ethylisocyanide 
• 1264366-68-8 C₃₁H₃₀N₂O₅ 
• 1264366-82-6 N-{[2-(4-benzyloxy)phenyl]ethyl}-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide 
• 1264366-69-9 C₂₉H₂₈N₂O₆ 
• 1264366-83-7 N-{[2-(4-benzyloxy)phenyl]ethyl}-2-(3-furyl)-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide 
• 1264366-93-9 N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide 
• 1264366-94-0 2-(3-furyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide 
• 68898-82-8 (E)-3-[4-(2-{[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyl]-methyl-amino}-ethyl)-phenoxy]-acrylic acid benzyl ester 
• 68898-81-7 (E)-3-(4-{2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-ethyl}-phenoxy)-acrylic acid benzyl ester 
• 68898-84-0 3-[4-(2-{[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyl]-methyl-amino}-ethyl)-phenoxy]-propionic acid 
• 68898-77-1 ((S)-1-{[2-(4-Benzyloxy-phenyl)-ethyl]-methyl-carbamoyl}-3-methyl-butyl)-methyl-carbamic acid tert-butyl ester 
• 68898-76-0 ((S)-1-{[2-(4-Benzyloxy-phenyl)-ethyl]-methyl-carbamoyl}-3-methyl-butyl)-carbamic acid tert-butyl ester 
• 68898-83-9 3-(4-{2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-ethyl}-phenoxy)-propionic acid 
• 68898-79-3 ((S)-1-{[2-(4-Hydroxy-phenyl)-ethyl]-methyl-carbamoyl}-3-methyl-butyl)-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Tandem Ugi MCR/mitsunobu cyclization as a short, protecting-group-free route to benzoxazinones with four diversity points

A tandem Ugi/Mitsunobu protocol, starting from o-aminophenols, α-hydroxy acids, amines and aldehydes gives benzo[b][1,4]oxazin-3-ones of general formula 1 in two high-yielding steps, with the introduction of up to four diversity inputs. The mildness of the methodology allows the stereospecific synthesis of enantiomerically pure products as well as the introduction of additional functional groups. The overall procedure can also be carried out in a one-pot manner. A tandem Ugi/Mitsunobu protocol, starting from o-aminophenols and α-hydroxy acids, gives benzo[b][1,4]oxazin-3-ones, with the introduction of up to four diversity inputs, in two high-yielding steps. The procedure may be carried out in a one-pot fashion and has a very broad scope, also allowing the synthesis of enantiomerically pure products.

PROCESS FOR PREPARATION OF BENZAZEPINE

This invention discloses a process for manufacture of galanthamine, which involves a stereoselective reduction step to get the desired isomer of galanthamine. The current embodiment also discusses the method for improving the chiral and chemical purity of galanthamine and galanthamine salts.