- Identification and characterization of m1 selective muscarinic receptor antagonists1
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A series of esters of 1,4-disubstituted tetrahydropyridine carboxylic acids (I) has been synthesized and characterized as potential ml selective muscarinic receptor antagonists. The affinity of these compounds for the five human muscarinic receptor subtyp
- Augelli-Szafran, Corinne E.,Blankley, C. John,Jaen, Juan C.,Moreland, David W.,Nelson, Carrie B.,Penvose-Yi, Jan R.,Schwarz, Roy D.,Thomas, Anthony J.
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p. 356 - 363
(2007/10/03)
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- SOLVENT AND TEMPERATURE EFFECTS ON THE NUCLEOPHILIC ADDITION OF ORGANOLITHIUMS TO 3-(4,4-DIMETHYLOXAZOLIN-2-YL)PYRIDINE. SYNTHESIS OF STABILIZED 1,2-, 1,4- AND/OR 1,6-DIHYDROPYRIDINES
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The reaction of 3-(4,4-dimethyloxazolin-2-yl)pyridine (1) with nucleophilic organolithium reagents afforded stabilized N-unsubstituted 1,2-, 1,4- and/or 1,6-dihydropyridines.Reaction of 1 with phenyllithium gave a mixture of 1,2- (2) and 1,4-dihydropyridi
- Dubey, Sushil K.,Knaus, Edward E.
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p. 125 - 134
(2007/10/02)
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- THE REGIOSELECTIVE NUCLEOPHILIC ADDITION OF ORGANOLITHIUMS TO 3-(4,4-DIMETHYLOXAZOLIN-2-YL)PYRIDINE. SYNTHESIS OF 1,2-, 1,4- AND/OR 1,6-DIHYDROPYRIDINES
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The nucleophilic addition of organolithium reagents to 3-(4,4-dimethyloxazolin-2-yl)pyridine afforded stabilized N-substituted 1,2-, 1,4- and/or 1,6-dihydropyridines.Solvent, temperature and nature of the organolithium reagent influence the regioselectivi
- Dubey, Sushil K.,Knaus, Edward E.,Giam, Choo-Seng
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p. 1091 - 1093
(2007/10/02)
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- Substitutions on Pyridines Activated by Oxazolines via Nucleophilic Additions or Metalation-Alkylation
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Pyridyloxazolines, derived from nicotinic acid or isonicotinic acid, have been shown to metalate at the 4- and 3-positions, respectively.These react with a variety of electrophiles to provide 4- and 3-substituted pyridines in good yield.Alternatively, 3-pyridyloxazolines, when treated with organolithium or Grignard reagents, give addition to the 4-position and provide a series of 4-substituted 1,4-dihydropyridines.
- Meyers, A. I.,Gabel, Richard A.
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p. 2633 - 2637
(2007/10/02)
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- Regioselective Nucleophilic Addition of Organolithium Compounds to 3-(4,4-Dimethyloxazolin-2-yl)pyridine
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The nucleophilic heteroaromatic addition reactions of 3-(4,4-dimethyloxazolin-2-yl)pyridine (8) with organolithium compounds as nucleophilic reagents have been investigated.Strongly nucleophilic reagents have been observed to add preferentially to the γ-
- Hauck, Albert E.,Giam, Choo-Seng
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p. 2070 - 2076
(2007/10/02)
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