68981-78-2Relevant academic research and scientific papers
Identification and characterization of m1 selective muscarinic receptor antagonists1
Augelli-Szafran, Corinne E.,Blankley, C. John,Jaen, Juan C.,Moreland, David W.,Nelson, Carrie B.,Penvose-Yi, Jan R.,Schwarz, Roy D.,Thomas, Anthony J.
, p. 356 - 363 (2007/10/03)
A series of esters of 1,4-disubstituted tetrahydropyridine carboxylic acids (I) has been synthesized and characterized as potential ml selective muscarinic receptor antagonists. The affinity of these compounds for the five human muscarinic receptor subtyp
SOLVENT AND TEMPERATURE EFFECTS ON THE NUCLEOPHILIC ADDITION OF ORGANOLITHIUMS TO 3-(4,4-DIMETHYLOXAZOLIN-2-YL)PYRIDINE. SYNTHESIS OF STABILIZED 1,2-, 1,4- AND/OR 1,6-DIHYDROPYRIDINES
Dubey, Sushil K.,Knaus, Edward E.
, p. 125 - 134 (2007/10/02)
The reaction of 3-(4,4-dimethyloxazolin-2-yl)pyridine (1) with nucleophilic organolithium reagents afforded stabilized N-unsubstituted 1,2-, 1,4- and/or 1,6-dihydropyridines.Reaction of 1 with phenyllithium gave a mixture of 1,2- (2) and 1,4-dihydropyridi
THE REGIOSELECTIVE NUCLEOPHILIC ADDITION OF ORGANOLITHIUMS TO 3-(4,4-DIMETHYLOXAZOLIN-2-YL)PYRIDINE. SYNTHESIS OF 1,2-, 1,4- AND/OR 1,6-DIHYDROPYRIDINES
Dubey, Sushil K.,Knaus, Edward E.,Giam, Choo-Seng
, p. 1091 - 1093 (2007/10/02)
The nucleophilic addition of organolithium reagents to 3-(4,4-dimethyloxazolin-2-yl)pyridine afforded stabilized N-substituted 1,2-, 1,4- and/or 1,6-dihydropyridines.Solvent, temperature and nature of the organolithium reagent influence the regioselectivi
Substitutions on Pyridines Activated by Oxazolines via Nucleophilic Additions or Metalation-Alkylation
Meyers, A. I.,Gabel, Richard A.
, p. 2633 - 2637 (2007/10/02)
Pyridyloxazolines, derived from nicotinic acid or isonicotinic acid, have been shown to metalate at the 4- and 3-positions, respectively.These react with a variety of electrophiles to provide 4- and 3-substituted pyridines in good yield.Alternatively, 3-pyridyloxazolines, when treated with organolithium or Grignard reagents, give addition to the 4-position and provide a series of 4-substituted 1,4-dihydropyridines.
Regioselective Nucleophilic Addition of Organolithium Compounds to 3-(4,4-Dimethyloxazolin-2-yl)pyridine
Hauck, Albert E.,Giam, Choo-Seng
, p. 2070 - 2076 (2007/10/02)
The nucleophilic heteroaromatic addition reactions of 3-(4,4-dimethyloxazolin-2-yl)pyridine (8) with organolithium compounds as nucleophilic reagents have been investigated.Strongly nucleophilic reagents have been observed to add preferentially to the γ-
