- Method for synthesizing anticoccidial drug toltrazuril for animals
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The invention discloses a method for synthesizing an anticoccidial drug toltrazuril. The method comprises the following steps: mixing 3-methyl-4-(4-trifluoromethylthio-phenoxy)aniline with methylaminoformyl chloride, reacting in an organic solvent A at 30-100 DEG C for 1-6 h, carrying out post-treatment on a reaction solution A obtained after the reaction is completed, dissolving the obtained 1-methyl-3-[3-methyl-4-(4-trifluoromethylthio-phenoxy)phenyl]urea crude product into an organic solvent B, adding an inorganic acid at 0-40 DEG C, carrying out a reaction for 1-5 h, adding an aqueous cyanate solution, carrying out a thermal insulation reaction for 2-12 h at 35-50 DEG C to obtain a reaction solution B, and carrying out post-treatment to obtain 3-methyl-1-[3-methyl-4-(4-trifluoromethylthiophenoxy)phenyl]biuret; and mixing diethyl carbonate with an alkaline substance, adding the 3-methyl-1-[3-methyl-4-(4-trifluoromethylthiophenoxy)phenyl]biuret at 40-80 DEG C, carrying out a heat preservation reaction for 2-8 h in an organic solvent C to obtain a reaction solution C, and carrying out post-treatment to obtain the pure toltrazuril product. The method adopts cheap and readily available raw materials, has mild reaction conditions, and is environment-friendly and safe.
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Paragraph 0047-0053
(2020/06/05)
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- Preparation of ponazuril and toltrazuril
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The invention relates to preparation of ponazuril and toltrazuril, in particular to a reaction of 1-(4-halogenated-3-methylphenyl)-3-methyl-1,3,5-triazine-2,4,6-trione and p-substituted phenol in thepresence of a copper catalyst/alkali/additive/solvent. The process is simple to operate and has an industrial large-scale production prospect.
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Paragraph 0017; 0020
(2020/06/09)
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- Process for preparing 1,3,5-triazinetriones
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The novel process STR1 gives the end products, known as animal growth-promoters and coccidiostatics. Intermediates II are new.
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- Process for preparing 1,3,5-triazinetriones
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The novel process STR1 gives the end products, known as animal growth-promoters and cooccidiostatics. Intermediates II are new.
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