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Toltrazuril
Cas No: 69004-03-1
USD $ 170.0-173.0 / Kilogram 25 Kilogram 500 Metric Ton/Month Arshine Pharmaceutical Co., Limited Contact Supplier
Toltrazuril\factory\good quality\anticoccidial
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Toltrazuril anticoccidial
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Factory supply 99% Toltrazuril powder
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USD $ 100.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Year Sinoway Industrial Co., Ltd. Contact Supplier
99% Powder Toltrazuril CAS 69004-03-1
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USD $ 0.06-0.06 / Gram 1 Gram 6000 Kilogram/Day Wuhan Kanal Technology Co., Ltd. Contact Supplier
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toltrazuril CAS NO.69004-03-1
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69004-03-1 Usage

Chemical Properties

Toltrazuril is white or off-white color crystalline powder, and odorless is molten in the methanol part omitted at ethyl acetate, dichloromethane, Polyethylene Glycol, α-adjoin in the organic solvents such as pyrrolidone, propylene glycol and dissolve, and is insoluble in water. Toltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications. The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.

Veterinary Drugs and Treatments

Toltrazuril is an antiprotozoal agent that may be considered as an alternative treatment for coccidiosis in dogs and cats, Hepatazoon infections, or for treating the oocyst shedding stage of toxoplasmosis in cats. It has also been used as a treatment for overwhelming parasitic loads in lizards (Bearded Dragons). Toltrazuril has activity against parasites of the genus Hepatozoon, but other drugs (e.g., imidocarb, primaquine, doxycycline) are generally used. While toltrazuril has been used to treat equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona, use of approved products now available (e.g., nitazoxanide, ponazuril, pyrimethamine/ sulfadiazine) is preferred. Toltrazuril has been used in some countries to treat Isospora suis in piglets.

Uses

Labelled analog of a triazinetrione anticoccidial. Coccidiostat. Toltrazuril is found to be highly effective against coccidia and is used in controlling coccidiosis. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.

Description

Toltrazuril (Baycox?,Procox?) is a triazinon drug thathas broad-spectrum anticoccidial and antiprotozoalactivity. It is not commercially available in the UnitedStates, but it is available in other countries. It is activeagainst both asexual and sexual stages of coccidia byinhibiting nuclear division of schizonts and microga-monts and the wall-forming bodies of macrogamonts. Itmay also be useful in the treatment of neonatal porcinecoccidiosis, EPM, and canine hepatozoonosis. Toltrazuril and its major metabolite ponazuril (toltrazuril sulfone, Marquis) are triazine-based antiprotozoal drugs that have specific activity against apicomplexan coccidial infections. Toltrazuril is not available within the United States.

Uses

tranquilizer

Clinical Use

Swine: Toltrazuril has been shown to reduce the signs of coccidiosis in naturally infected nursing pigs when a single oral 20–30 mg/kg BWdose is given to 3 to 6-dayold pigs (Driesen et al., 1995). Clinical signs were reduced from 71 to 22% of nursing pigs, and diarrhea and oocyst excretion were also decreased by the single oral treatment. Approved products carry a 77-daywithdrawal time in the United Kingdom. Calves and lambs: Toltrazuril is used for the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in calves and lambs as a single dose treatment. Withdrawal times in the United Kingdom are 63 and 42 days for calves and lambs, respectively. Dogs: For hepatozoonosis, toltrazuril given orally at 5 mg/kg BW every 12 hours for 5 days or given orally at 10 mg/kg BW every 12 hours for 10 days caused remission of clinical signs in naturally infected dogs in 2–3 days (Macintire et al., 2001). Unfortunately, most treated dogs relapsed and eventually died from hepatozoonosis. In puppies with Isospora sp. infection, treatment with 0.45 mg emodepside in combination with 9 mg/kg BW toltrazuril (Procox?, Bayer Animal Health) reduces fecal oocyst count by 91.5–100%. There was no difference in duration of diarrhea when treatment was begun after the onset of clinical signs during patent infection (Altreuther et al., 2011). Cats: In kittens experimentally infected with Isospora spp., treatment with a single oral dose of 0.9 mg emodepside in combination with 18 mg/kg BW toltrazuril (Procox?, Bayer AnimalHealth) reduces oocyst shedding by 96.7–100% if given during the prepatent period (Petry et al., 2011). Horses: Toltrazuril has also been used for the treatment of EPM. This drug is safe, even at high doses. Current recommended treatments are 5–10 mg/kg orally for 28 days. Despite the favorable efficacy with toltrazuril, its use has diminished in horses because of better availability of other effective drugs.

Environmental Fate

The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.
InChI:InChI=1/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

69004-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Toltrazuril

1.2 Other means of identification

Product number -
Other names 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfanyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:69004-03-1 SDS

69004-03-1Synthetic route

3-methyl-1-[3-methyl-4-(4-(trifluoromethylsulfanyl)phenoxy)phenyl]biuret
106310-18-3

3-methyl-1-[3-methyl-4-(4-(trifluoromethylsulfanyl)phenoxy)phenyl]biuret

Diethyl carbonate
105-58-8

Diethyl carbonate

toltrazuril
69004-03-1

toltrazuril

Conditions
ConditionsYield
Stage #1: 3-methyl-1-[3-methyl-4-(4-(trifluoromethylsulfanyl)phenoxy)phenyl]biuret; Diethyl carbonate With sodium methylate In toluene at 50℃; for 4h;
Stage #2: With acetic acid In water; toluene at 70℃; pH=7; Reagent/catalyst; Solvent; Temperature;
81%
With sodium methylate In water
(4-trifluoromethylthio)phenol
461-84-7

(4-trifluoromethylthio)phenol

1-(4-iodo-3-methylphenyl)-3-methyl-1,3,5-triazine-2,4,6-trione

1-(4-iodo-3-methylphenyl)-3-methyl-1,3,5-triazine-2,4,6-trione

toltrazuril
69004-03-1

toltrazuril

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; N-(2-phenylphenyl)-N′-benzyl oxalamide In acetonitrile at 90℃; for 24h; Inert atmosphere;80.6%
N-methyl-N'-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide
106310-17-2

N-methyl-N'-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide

Diethyl carbonate
105-58-8

Diethyl carbonate

toltrazuril
69004-03-1

toltrazuril

Conditions
ConditionsYield
With sodium methylate In water
3-methyl-4-{4-[(trifluoromethyl)sulfanyl]phenoxy}aniline
94155-78-9

3-methyl-4-{4-[(trifluoromethyl)sulfanyl]phenoxy}aniline

toltrazuril
69004-03-1

toltrazuril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 3 h / 60 °C
2.1: acetic acid / N,N-dimethyl-formamide / 1.33 h
2.2: 10 h / 40 °C
3.1: sodium methylate / toluene / 4 h / 50 °C
3.2: 70 °C / pH 7
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 3 h / 60 °C
2.1: acetic acid / N,N-dimethyl-formamide / 1.33 h
2.2: 9.5 h / 40 °C
3.1: sodium methylate / toluene / 4 h / 50 °C
3.2: 70 °C / pH 7
View Scheme
1-methyl-3-[3-methyl-4-(4-trifluoromethylthiophenoxy)phenyl]urea

1-methyl-3-[3-methyl-4-(4-trifluoromethylthiophenoxy)phenyl]urea

toltrazuril
69004-03-1

toltrazuril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / N,N-dimethyl-formamide / 1.33 h
1.2: 10 h / 40 °C
2.1: sodium methylate / toluene / 4 h / 50 °C
2.2: 70 °C / pH 7
View Scheme
toltrazuril
69004-03-1

toltrazuril

1-[3-methyl-4-(4-(trifluoromethylthio)phenoxy)phenyl]-3-methyl-1,3,5-triazine-2,4,6-trione potassium salt

1-[3-methyl-4-(4-(trifluoromethylthio)phenoxy)phenyl]-3-methyl-1,3,5-triazine-2,4,6-trione potassium salt

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; for 4h; Solvent;49 g
toltrazuril
69004-03-1

toltrazuril

1-[3-methyl-4-(4-(trifluoromethylthio)phenoxy)phenyl]-3-methyl-1,3,5-triazine-2,4,6-trione sodium salt

1-[3-methyl-4-(4-(trifluoromethylthio)phenoxy)phenyl]-3-methyl-1,3,5-triazine-2,4,6-trione sodium salt

Conditions
ConditionsYield
With sodium hydroxide In acetone at 20℃; for 3h;
benzyl 6-bromohexanoate
78277-26-6

benzyl 6-bromohexanoate

toltrazuril
69004-03-1

toltrazuril

C31H30F3N3O6S

C31H30F3N3O6S

Conditions
ConditionsYield
at 60℃; for 24h;
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