- Preparation method of 2-fluorine-5-trifluoromethylpyridine
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The invention discloses a preparation method of 2-fluorine-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. The method comprises the following steps: (1) chlorinating 3-methylpyridine serving as a raw material by one step, thus synthesizing a coarse 2-chlorine-5-trichloromethylpyridine product; (2) fluorinating purified 2-chlorine-5-trichloromethylpyridine serving as a raw material and anhydrous HF serving as a fluorinating reagent by one step, thus synthesizing a coarse 2-fluorine-5-trifluoromethylpyridine product; (3) carrying out reduced pressure distillation on an oil layer subjected to alkali and water washing, thus obtaining high-purity 2-fluorine-5-trifluoromethylpyridine. The preparation method has the advantages of high transformation rate, good reaction selectivity, low production cost and suitability for industrial production.
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Paragraph 0030; 0032; 0044; 0046
(2017/07/21)
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- Efficient indium-mediated dehalogenation of aromatics in ionic liquid media
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An efficient indium-mediated dehalogenation reaction of haloaromatics and haloheteroaromatics in ionic liquids has been studied. This method is simple and effective in the presence of [bmim]Br. Furthermore, this methodology is environmentally friendly compared with conventional ones.
- Canete, Alvaro F.,Salas, Cristian O.,Zacconi, Flavia C.
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p. 398 - 407
(2013/03/13)
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