69045-82-5

Basic information

• Product Name: 2-Fluoro-5-trifluoromethylpyridine
• Synonyms: 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;2-Fluoro-5-(Trichloromethyl)Py;2-Fluoro-5-(trifluoromethyl)pyridine ,98%;Pyridine, 2-fluoro-5-(trifluoroMethyl)-;2-Fluoro-5-(trifluoromethyl)pyridine 97%
• CAS NO: 69045-82-5
• Molecular Formula: C₆H₃F₄N
• Molecular Weight: 165.09
• EINECS: 400-290-2
• Product Categories: pharmacetical;Halides;Pyridines;Pyridine;Fluorine series
• Mol File: 69045-82-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 118-122℃
• Flash Point: 35°(95°F)
• Appearance: /
• Density: 1.368 g/mL at 25 °C
• Vapor Pressure: 9.61mmHg at 25°C
• Refractive Index: 1.4020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.86±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-5-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-trifluoromethylpyridine(69045-82-5)
• EPA Substance Registry System: 2-Fluoro-5-trifluoromethylpyridine(69045-82-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-52/53-43-10
• Safety Statements: 26-36/37/39-45-61-37-24-36-27
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 69045-82-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

Upstream product

• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 

Downstream Products

• 145834-67-9 1-(4-fluorophenyl)-2-[5-(trifluoromethyl)-2-pyridyl]ethanone 
• 1000998-44-6 4-methyl-3-phenyl-2-(5-trifluoromethylpyridin-2-yl)-2H-pyrano[2,3-c]pyrazol-6-one 
• 1000998-45-7 4-methyl-3-phenyl-1-(5-trifluoromethylpyridin-2-yl)-1H-pyrano[2,3-c]pyrazol-6-one 
• 1623733-97-0 (S)-4-((2-oxopyrrolidin-3-yl)amino)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1,3,5-triazine-2-carboxamide 
• 1623733-94-7 (S)-4-((2-oxopyrrolidin-3-yl)amino)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1,3,5-triazine-2-carbonitrile 
• 103962-21-6 4-[{5-(trifluoromethyl)pyridin-2-yl}oxy]benzaldehyde 
• 145833-95-0 4,5-dihydro-3-(4-fluorophenyl)-N-(4-trifluoromethylphenyl)-4-(5-trifluoromethyl-2-pyridyl)-1H-pyrazole-1-carboxamide 

Relevant articles and documents

Preparation method of 2-fluorine-5-trifluoromethylpyridine

The invention discloses a preparation method of 2-fluorine-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. The method comprises the following steps: (1) chlorinating 3-methylpyridine serving as a raw material by one step, thus synthesizing a coarse 2-chlorine-5-trichloromethylpyridine product; (2) fluorinating purified 2-chlorine-5-trichloromethylpyridine serving as a raw material and anhydrous HF serving as a fluorinating reagent by one step, thus synthesizing a coarse 2-fluorine-5-trifluoromethylpyridine product; (3) carrying out reduced pressure distillation on an oil layer subjected to alkali and water washing, thus obtaining high-purity 2-fluorine-5-trifluoromethylpyridine. The preparation method has the advantages of high transformation rate, good reaction selectivity, low production cost and suitability for industrial production.

Non-basic histamine H1-antagonists. I. Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds

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