693-92-5

Basic information

• Product Name: 3-METHYLISOTHIAZOLE
• Synonyms: 3-METHYLISOTHIAZOLE;3-methyl-1,2-thiazole;2,3-DiMethyl-isothiazoliuM
• CAS NO: 693-92-5
• Molecular Formula: C₄H₅NS
• Molecular Weight: 99.15
• Mol File: 693-92-5.mol

Chemical Properties

• Melting Point: 167-168℃ (water )
• Boiling Point: 134℃
• Flash Point: -15.8±13.0℃
• Appearance: /
• Density: 1.121±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 309mmHg at 25°C
• Refractive Index: 1.5180 (589.3 nm 21℃)
• PKA: 4.67±0.12(Predicted)
• CAS DataBase Reference: 3-METHYLISOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLISOTHIAZOLE(693-92-5)
• EPA Substance Registry System: 3-METHYLISOTHIAZOLE(693-92-5)

Safety Data

• Hazardous Substances Data: 693-92-5(Hazardous Substances Data)

Usage

Uses

Used in the Food Industry:
3-Methylisothiazole is used as a flavoring agent for its distinctive aromatic properties, enhancing the taste and aroma of various food products.
Used in the Oil and Gas Industry:
In this sector, 3-Methylisothiazole serves as a corrosion inhibitor, helping to protect equipment and infrastructure from the damaging effects of corrosive substances.
Used as a Bioocide:
3-Methylisothiazole is utilized as a biocide due to its antimicrobial properties, which are effective against a range of microorganisms, making it useful for controlling microbial growth in various applications.
Used in Personal Care Products:
3-METHYLISOTHIAZOLE is used as a fragrance ingredient in personal care products, contributing to the scent profile of items such as perfumes, soaps, and lotions.
Used as a Preservative:
Leveraging its antimicrobial characteristics, 3-Methylisothiazole is employed as a preservative in a variety of products to extend their shelf life and maintain product integrity.

InChI:InChI=1/C4H5NS/c1-4-2-3-6-5-4/h2-3H,1H3

Upstream product

• 66975-83-5 3-methyl-5-isothiazolecarboxylic acid 
• 24340-76-9 3-methyl-5-aminothiazole 
• 693-95-8 4-Methylthiazole 
• 71134-43-5 3-methyl-5-aminoisothiazole hydrochloride 
• 1423-60-5 methyl ethynyl ketone 

Downstream Products

• 1073-18-3 3-Methyl-4-nitro-isothiazol 
• 3119-61-7 2-Benzyl-3-methyl-isothiazolium 
• 17265-43-9 (4-chloro-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 17265-44-0 (3-methyl-isothiazol-5-yl)-phenyl-methanol 
• 2939-03-9 2-<2-Nitro-benzyl>-3-methyl-isothiazolium 
• 2939-04-0 2-<3-Nitro-benzyl>-3-methyl-isothiazolium 
• 3219-92-9 2-<4-Nitro-benzyl>-3-methyl-isothiazolium 
• 930-42-7 4-bromo-3-methylisothiazole 
• 4576-90-3 3-isothiazolecarboxylic acid 
• 10271-91-7 isothiazol-3-yl-acetic acid 
• 90672-16-5 (4-Benzyloxy-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-24-5 (3,4-Dimethyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-08-5 (4-tert-Butyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 90672-04-1 (2-Isopropyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 

Relevant articles and documents

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

(1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds, which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. The novel compounds include compounds of formula I: (I) wherein X, R1, and R2 are as herein defined.

Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains

The synthesis of novel 1β-methylcarbapenems 1a,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative 1a exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem.

Phototransposition Chemistry of Methylisothiazoles and Methylthiazoles

Methylisothiazoles undergo phototransition in neutral solution to methylthiazoles by a single permutation process.Methylisothiazole -> methylisothiazole transpositions, previously reported to occur, were not detected in these reactions.In trifluoroacetic acid solvent, protonated methylisothiazoles and methylthiazoles phototranspose by P4 and P5 permutation pathways, respectively, resulting in a unique phototransposition cycle.