24340-76-9

Basic information

• Product Name: 3-methylisothiazol-5-amine
• Synonyms: 3-methylisothiazol-5-amine;3-METHYL-5-ISOTHIAZOLAMINE;5-IsothiazolaMine,3-Methyl-;3-Methyl-isothiazol-5-ylamine
• CAS NO: 24340-76-9
• Molecular Formula: C₄H₆N₂S
• Molecular Weight: 114.16884
• EINECS: 246-176-4
• Mol File: 24340-76-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 52-53 °C
• Boiling Point: 120.7 °C at 760 mmHg
• Flash Point: 26.8 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 15mmHg at 25°C
• Refractive Index: 1.618
• PKA: 8.45±0.50(Predicted)
• CAS DataBase Reference: 3-methylisothiazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylisothiazol-5-amine(24340-76-9)
• EPA Substance Registry System: 3-methylisothiazol-5-amine(24340-76-9)

Safety Data

• Hazardous Substances Data: 24340-76-9(Hazardous Substances Data)

Usage

Description

3-Methylisothiazol-5-amine is an organic compound with the molecular formula C4H6N2S. It is a heterocyclic compound featuring a five-membered isothiazol ring with a methyl group and an amine functional group. 3-methylisothiazol-5-amine is known for its chemical reactivity and is utilized in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Synthesis:
3-Methylisothiazol-5-amine is used as a synthetic reagent for the creation of pyrrolidinyl ureas, which are potent FPR2 selective agonists. These agonists play a crucial role in the prevention and treatment of heart failure, making this compound an essential component in the development of novel therapeutic strategies for cardiovascular health.

InChI:InChI=1/C4H6N2S/c1-3-2-4(5)7-6-3/h2H,5H2,1H3

Upstream product

• 62069-87-8 β-aminothiocrotonic acid amide 
• 71134-43-5 3-methyl-5-aminoisothiazole hydrochloride 
• 22131-51-7 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid 
• 25391-97-3 5-benzoylamino-3-methyl-4-isothiazolecarboxylic acid 
• 32081-55-3 3-amino-but-2-enethioic acid amide 

Downstream Products

• 52724-43-3 4-acetylamino-N-(3-methyl-isothiazol-5-yl)-benzenesulfonamide 
• 20067-16-7 5-Chlor-3-methyl-isothiazol 
• 57861-24-2 2-(3-methyl-isothiazol-5-ylamino)-benzoic acid 
• 25039-57-0 3-methyl-4-phenylazo-isothiazol-5-ylamine 
• 747357-66-0 2,3-dimethyl-2H-isothiazol-5-ylideneamine 
• 71109-34-7 3-methyl-1,2-thiazolo<5,4-b>pyridine 
• 25039-55-8 4-(3-methyl-isothiazol-5-ylazo)-phenol 
• 693-92-5 3-methylisothiazole 
• 85508-99-2 4-bromo-3-methyl-isothiazol-5-amine 
• 36778-16-2 3-methyl-5-nitroisothiazole 
• 4590-59-4 5-Amino-3-methyl-isothiazol-4-sulfonsaeure 
• 88090-93-1 5-(2-amino-2-methylvinyl)-3-p-chlorophenyl-1,2,4-thiadiazole 
• 71079-27-1 N-cyclohexyl-N'-(3-methyl-isothiazol-5-yl)-N''-(2-methyl-quinolin-4-yl)-guanidine 
• 141859-13-4 5--3-methylisothiazole 

Relevant articles and documents

New and simple route to derivatives of isothiazolo[5,4-b] pyridine

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Methods for inhibiting protein kinases

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.