- Improved synthesis dimethylhomoecoerdianthrone (HOCD) and its functionalization through facile amination reactions
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An improved synthesis of dimethylhomoecoerdianthrone (HOCD), a dye used for singlet oxygen detection, was reported by isolation of a key intermediate followed by cyclization reaction. Moreover, dehydrogenative amination reaction between HOCD and alkyl ami
- Wu, Haixia,Chen, Wei,Yang, Hui,Wang, Suhua,Lim, Si Ting,Yao, Wei,Guo, Juanjuan,Li, Tianhu,Wong, Ming Wah,Huang, Dejian
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- Dye and fluorescent probe for detecting singlet oxygen and manufacturing method of dye and fluorescent probe
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The application discloses a synthetic method of a dye compound used for sensitive detection of singlet oxygen. Furthermore, a fluorescent probe having a part of different fluorescent groups of the dye compound is designed and is synthesized through a new
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- Synthesis of new polycyclic anthracenedione analogs with hetero- Or carbocyclic ring(s) fused to the chromophore system
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A series of novel anthracenedione analogs with various hetero- or carbocyclic ring(s) incorporated into the chromophore has been synthesized. These compounds may constitute a new class of anthracenedione agents with potential ability to overcome multidrug resistance of cancer cells.
- Dzieduszycka,Stefanska,Gawronska,Arciemiuk,Borowski
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p. 535 - 545
(2008/09/17)
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- 1,4-disubstituted anthracene antitumor agents
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Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug- resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino)ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4- diamide was more potent across the tumor panel than the corresponding 9,10- isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,4-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.
- Iyengar, Bhashyam S.,Dorr, Robert T.,Alberts, David S.,Sólyom, Anikó M.,Krutzsch, Mary,Remers, William A.
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p. 3734 - 3738
(2007/10/03)
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