69434-23-7

Upstream product

• 80817-34-1 N-6-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine 3'-(o-chlorophenyl β-cyanoethyl phosphate) 
• 109-78-4 3-Hydroxypropionitrile 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 76958-61-7 [1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 15074-54-1 2-chlorophenyl dichlorophosphate 
• 958-09-8 2'-deoxy-D-adenosine 
• 64723-02-0 N-benzoyl-3',5'-di-O-benzoyl-2'-deoxyadenosine 
• 4546-72-9 N₆-benzoyl-2'-deoxyadenosine 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Downstream Products

• 75269-16-8 <(MeO)2Tr>bzA_dΦbzA_dΦ(CNEt) 
• 78111-53-2 <(MeO)2Tr>ibG_dΦbzA_dΦ(CNEt) 
• 78111-49-6 C₆₃H₅₈Cl₂N₈O₁₆P₂ 
• 78111-50-9 C₆₉H₆₁Cl₂N₉O₁₆P₂ 
• 85240-06-8 C₄₉H₄₃Cl₂N₁₁O₁₃P₂ 
• 94940-31-5 C₆₀H₅₅Cl₂N₇O₁₆P₂*C₆H₁₅N 

Relevant academic research and scientific papers

Synthesis of symmetric oligo-DNA dimers and their formation of polymeric supramolecular assembly

p-Hydroxybenzene was coupled with tetrathymidine or tetraadenosine through phosphodiester bonds to give symmetric oligo-DNA dimers, (T4)2Bz and (A4)2Bz, as components for a polymeric supramolecular assembly. The equivalent mixture of them formed a high-molecular-weight aggregate in aqueous media via complemental hydrogen bonds.

Simplified Liquid-Phase Preparation of Four Decadeoxyribonucleotides and their Preliminary Spectroscopic Characterization

Four self-complementary decadeoxyribonucleotides, dApTpApTpApTpApTpApT,dApTpApTpCpGpApTpApT, dApTpApTpGpCpApTpApT and dApApApApApTpTpTpTpT, were chemically synthesized by the phosphotriester procedure.Efforts were concentrated on keeping the procedure as simple as possible, concomitant with obtaining high-purity products at each step of the process.The decamers were elaborated from the 3'-end, starting with a 3'-O-benzoylated monomer according to the scheme: monomer + monomer -> dimer + dimer -> tetramer + dimer -> hexamer + tetramer -> decamer.Putity of intermediates and of the fully blocked decamers were monitored by chromatography and by 300-MHz 1H-NMR. spectroscopy.The deblocked decadeoxyribonucleotides were characterized by their UV., CD., and 1H-NMR. spectra.

SELECTIVE N-DEACYLATION OF N,O-PROTECTED NUCLEOSIDES BY ZINC BROMIDE

N-Acyl protecting group in nucleoside derivatives can be selectively removed by treatment with zinc bromide in the presence of alcohols to give O-protected nucleosides.